Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation

Gomzikova, Marina O.; James, Victoria; Rizvanov, Albert A.

doi:10.3389/fimmu.2019.02663

Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation

Gomzikova, Marina O.; James, Victoria; Rizvanov, Albert A.

Authors

Marina O. Gomzikova

Professor VICTORIA JAMES VICTORIA.JAMES@NOTTINGHAM.AC.UK
PROFESSOR OF MOLECULAR BIOLOGY

Albert A. Rizvanov

Abstract

The immunosuppressive potential of mesenchymal stem cells has been extensively investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and clinical studies have demonstrated that mesenchymal stem cells ameliorate immune-mediated disorders, including autoimmune diseases. However, to date mesenchymal stem cells have not become a widely used therapeutic agent due to safety challenges, high cost and difficulties in providing long term production. A key mechanism underpinning the immunomodulatory effect of MSCs is the production of paracrine factors including growth factors, cytokines, chemokines, and extracellular vesicles (EVs). MSCs derived EVs have become an attractive therapeutic agent for immunomodulation and treatment of immune-mediated disorders. In addition to many preclinical studies of MSCs derived EVs, their beneficial effects have been observed in patients with both acute graft-vs.-host disease and chronic kidney disease. In this review, we discuss the current findings in the field of MSCs derived EVs-based therapies in immune-mediated disorders and approaches to scale EV production for clinical use.

Citation

Gomzikova, M. O., James, V., & Rizvanov, A. A. (2019). Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation. Frontiers in Immunology, 10, Article 2663. https://doi.org/10.3389/fimmu.2019.02663

Journal Article Type	Review
Acceptance Date	Oct 28, 2019
Online Publication Date	Nov 15, 2019
Publication Date	Nov 15, 2019
Deposit Date	Nov 20, 2019
Publicly Available Date	Nov 20, 2019
Journal	Frontiers in Immunology
Electronic ISSN	1664-3224
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	10
Article Number	2663
DOI	https://doi.org/10.3389/fimmu.2019.02663
Keywords	Extracellular vesicles, Microvesicles, Immunosuppression, Autoimmune diseases, Multiple sclerosis, Transplant rejection, Type 1 diabetes, Graft-vs.-host disease
Public URL	https://nottingham-repository.worktribe.com/output/3341277
Publisher URL	https://www.frontiersin.org/articles/10.3389/fimmu.2019.02663/full
Contract Date	Nov 20, 2019