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Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation

Gomzikova, Marina O.; James, Victoria; Rizvanov, Albert A.

Authors

Marina O. Gomzikova

Victoria James

Albert A. Rizvanov



Abstract

The immunosuppressive potential of mesenchymal stem cells has been extensively investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and clinical studies have demonstrated that mesenchymal stem cells ameliorate immune-mediated disorders, including autoimmune diseases. However, to date mesenchymal stem cells have not become a widely used therapeutic agent due to safety challenges, high cost and difficulties in providing long term production. A key mechanism underpinning the immunomodulatory effect of MSCs is the production of paracrine factors including growth factors, cytokines, chemokines, and extracellular vesicles (EVs). MSCs derived EVs have become an attractive therapeutic agent for immunomodulation and treatment of immune-mediated disorders. In addition to many preclinical studies of MSCs derived EVs, their beneficial effects have been observed in patients with both acute graft-vs.-host disease and chronic kidney disease. In this review, we discuss the current findings in the field of MSCs derived EVs-based therapies in immune-mediated disorders and approaches to scale EV production for clinical use.

Journal Article Type Review
Publication Date Nov 15, 2019
Journal Frontiers in Immunology
Electronic ISSN 1664-3224
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 10
Article Number 2663
APA6 Citation Gomzikova, M. O., James, V., & Rizvanov, A. A. (2019). Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation. Frontiers in Immunology, 10, https://doi.org/10.3389/fimmu.2019.02663
DOI https://doi.org/10.3389/fimmu.2019.02663
Keywords Extracellular vesicles, Microvesicles, Immunosuppression, Autoimmune diseases, Multiple sclerosis, Transplant rejection, Type 1 diabetes, Graft-vs.-host disease
Publisher URL https://www.frontiersin.org/articles/10.3389/fimmu.2019.02663/full

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