Marina O. Gomzikova
Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation
Gomzikova, Marina O.; James, Victoria; Rizvanov, Albert A.
Abstract
The immunosuppressive potential of mesenchymal stem cells has been extensively investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and clinical studies have demonstrated that mesenchymal stem cells ameliorate immune-mediated disorders, including autoimmune diseases. However, to date mesenchymal stem cells have not become a widely used therapeutic agent due to safety challenges, high cost and difficulties in providing long term production. A key mechanism underpinning the immunomodulatory effect of MSCs is the production of paracrine factors including growth factors, cytokines, chemokines, and extracellular vesicles (EVs). MSCs derived EVs have become an attractive therapeutic agent for immunomodulation and treatment of immune-mediated disorders. In addition to many preclinical studies of MSCs derived EVs, their beneficial effects have been observed in patients with both acute graft-vs.-host disease and chronic kidney disease. In this review, we discuss the current findings in the field of MSCs derived EVs-based therapies in immune-mediated disorders and approaches to scale EV production for clinical use.
Citation
Gomzikova, M. O., James, V., & Rizvanov, A. A. (2019). Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation. Frontiers in Immunology, 10, https://doi.org/10.3389/fimmu.2019.02663
Journal Article Type | Review |
---|---|
Acceptance Date | Oct 28, 2019 |
Online Publication Date | Nov 15, 2019 |
Publication Date | Nov 15, 2019 |
Deposit Date | Nov 20, 2019 |
Publicly Available Date | Mar 29, 2024 |
Journal | Frontiers in Immunology |
Electronic ISSN | 1664-3224 |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Article Number | 2663 |
DOI | https://doi.org/10.3389/fimmu.2019.02663 |
Keywords | Extracellular vesicles, Microvesicles, Immunosuppression, Autoimmune diseases, Multiple sclerosis, Transplant rejection, Type 1 diabetes, Graft-vs.-host disease |
Public URL | https://nottingham-repository.worktribe.com/output/3341277 |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fimmu.2019.02663/full |
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