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IFITMs mediate viral evasion in acute and chronic hepatitis C virus infection (2019)
Journal Article
Wrensch, F., Ligat, G., Heydmann, L., Schuster, C., Zeisel, M. B., Pessaux, P., …Baumert, T. F. (2019). IFITMs mediate viral evasion in acute and chronic hepatitis C virus infection. Hepatology, doi:10.1002/hep.30699

While adaptive immune responses against hepatitis C virus (HCV) infection have been studied in great detail, the role of innate immunity in protection against HCV infection and immune evasion is only partially understood. Interferon‐induced transmemb... Read More

Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir (2019)
Journal Article
Wing, P. A., Jones, M., Cheung, M., DaSilva, S., Bamford, C., Jason Lee, W., …Foster, G. R. (in press). Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir. Gastroenterology,

Background & Aims: Sofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections and resistance-associated substitutions in the polymerase are rare. However, HCV genotyp... Read More

Slow cycling intestinal stem cell and Paneth cell responses to Trichinella spiralis infection (2019)
Journal Article
Javkar, T., Hughes, K. R., Sablitzky, F., Behnke, J. M., & Mahida, Y. R. (2019). Slow cycling intestinal stem cell and Paneth cell responses to Trichinella spiralis infection. Parasitology International, doi:10.1016/j.parint.2019.05.001

There is limited information regarding responses by slow cycling stem cells during T. spiralis-induced T-cell mediated intestinal inflammation and how such responses may relate to those of Paneth cells. Transgenic mice, in which doxycycline induces e... Read More

GRK mediates μ-opioid receptor plasma membrane reorganization (2019)
Journal Article
Gondin, A. B., Halls, M. L., Canals, M., & Briddon, S. J. (2019). GRK mediates μ-opioid receptor plasma membrane reorganization. Frontiers in Molecular Neuroscience, doi:10.3389/fnmol.2019.00104

Differential regulation of the μ-opioid receptor (MOP) has been linked to the development of opioid tolerance and dependence which both limit the clinical use of opioid analgesics. At a cellular level, MOP regulation occurs via receptor phosphorylati... Read More

Molecular insights into an ancient form of Paget's disease of bone (2019)
Journal Article
Shaw, B., Burrell, C. L., Green, D., Navarro-Martinez, A., Scott, D., Daroszewska, A., …Layfield, R. (2019). Molecular insights into an ancient form of Paget's disease of bone. Proceedings of the National Academy of Sciences, doi:10.1073/pnas.1820556116

Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird (2019)
Journal Article
Kim, K., Jackson, B. C., Zhang, H., Toews, D. P. L., Taylor, S. A., Greig, E. I., …Burke, T. (2019). Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird. Nature Communications, 10(1), doi:10.1038/s41467-019-09806-6

Colour polymorphisms play a key role in sexual selection and speciation, yet the mechanisms that generate and maintain them are not fully understood. Here, we use genomic and transcriptomic tools to identify the precise genetic architecture and evolu... Read More

Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus (2019)
Journal Article
Taylor, C. H., Young, S., Fenn, J., Lamb, A. L., Lowe, A. E., Poulin, B., …Bradley, J. E. (2019). Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus. Functional Ecology, doi:10.1111/1365-2435.13354

1. The ability, propensity and need to mount an immune response vary both among individuals and within a single individual over time. 2. A wide array of parameters have been found to influence immune state in carefully controlled experiments, but... Read More

Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation (2019)
Journal Article
Negm, O. H., Singh, S., Abduljabbar, W., Hamed, M. R., Radford, P., McDermott, E. M., …Tighe, P. J. (2019). Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation. Clinical and Experimental Immunology, doi:10.1111/cei.13306

Tumour necrosis factor receptor‐associated periodic syndrome (TRAPS) is an hereditary autoinflammatory disorder characterised by recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNFRSF1A, which encod... Read More

Serogroup-specific meningococcal carriage by age group: a systematic review and meta-analysis (2019)
Journal Article
Peterson, M. E., Li, Y., Shanks, H., Mile, R., Nair, H., & Kyaw, M. H. (2019). Serogroup-specific meningococcal carriage by age group: a systematic review and meta-analysis. BMJ Open, 9(4), doi:10.1136/bmjopen-2018-024343

Objective Neisseria meningitidis carriage prevalence has known variation across the lifespan, but it is unclear whether carriage varies among meningococcal capsular groups. Therefore, we aimed to characterise group-specific meningococcal carriage by... Read More

A conserved protein, BcmA, mediates motility, biofilm formation, and host colonisation in Adherent Invasive Escherichia coli (2019)
Other
Cogger-Ward, R., Collins, A., McLean, D., Dehinsilu, J., & Huett, A. (2019). A conserved protein, BcmA, mediates motility, biofilm formation, and host colonisation in Adherent Invasive Escherichia coli

Adherent Invasive Escherichia coli (AIEC) is a non-diarrhoeagenic intestinal E. coli pathotype associated with Crohn’s Disease. AIEC pathogenesis is characterised by biofilm formation, adhesion to and invasion of intestinal epithelial cells, and intr... Read More

A retrospective analysis of responsible innovation for low-technology innovation in the Global South (2019)
Journal Article
Hartley, S., McLeod, C., Clifford, M., Jewitt, S., & Ray, C. (2019). A retrospective analysis of responsible innovation for low-technology innovation in the Global South. Journal of Responsible Innovation, doi:10.1080/23299460.2019.1575682

The role of low-technology innovation in addressing global challenges is undervalued. Responsible innovation (RI) has the potential to direct low-technology innovation toward global challenges in the Global South, yet this possibility remains largely... Read More

Engineering of vitamin prototrophy in Clostridium ljungdahlii and Clostridium autoethanogenum (2019)
Journal Article
Annan, F. J., Al-Sinawi, B., Humphreys, C. M., Norman, R., Winzer, , Köpke, M., …Henstra, A. M. (2019). Engineering of vitamin prototrophy in Clostridium ljungdahlii and Clostridium autoethanogenum. Applied Microbiology and Biotechnology, 103(11), 4633–4648. doi:10.1007/s00253-019-09763-6

Clostridium autoethanogenum and Clostridium ljungdahlii are physiologically and genetically very similar strict anaerobic acetogens capable of growth on carbon monoxide as sole carbon source. While exact nutritional requirements have not been reporte... Read More

Complex formation between VEGFR2 and the β2-adrenoceptor (2019)
Journal Article
Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., …Hill, S. J. (2019). Complex formation between VEGFR2 and the β2-adrenoceptor. Cell Chemical Biology, doi:10.1016/j.chembiol.2019.02.014

Vascular endothelial growth factor (VEGF) is an important mediator of endothelial cell proliferation and angiogenesis via its receptor VEGFR2. A common tumor associated with elevated VEGFR2 signaling is infantile hemangioma that is caused by a rapid... Read More

Whole genome duplication potentiates inter-specific hybridisation and niche shifts in Australian burrowing frogs Neobatrachus (2019)
Other
Novikova, P. Y., Brennan, I. G., Booker, W., Mahony, M., Doughty, P., Lemmon, A. R., …Donnellan, S. C. (2019). Whole genome duplication potentiates inter-specific hybridisation and niche shifts in Australian burrowing frogs Neobatrachus

Polyploidy plays an important role in evolution because it can lead to increased genetic complexity and speciation. It also provides an extra copy buffer and increases genetic novelty. While both common and well-studied in plants, polyploidy is rare... Read More

Azospirillum brasilense Az39, a model rhizobacterium with AHL quorum quenching capacity (2019)
Journal Article
Gualpa, J., Lopez, G., Nievas, S., Coniglio, A., Halliday, N., Cámara, M., & Cassán, F. (2019). Azospirillum brasilense Az39, a model rhizobacterium with AHL quorum quenching capacity. Journal of Applied Microbiology, 126(6), 1850-1860. doi:10.1111/jam.14269

Aims The aim of this research was to analyze the Quorum sensing (QS) and Quorum quenching (QQ) mechanisms based on N‐acyl‐L‐homoserine lactones (AHLs) in A. brasilense Az39, a strain with remarkable capacity to benefit a wide range of crops under... Read More

A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor (2019)
Journal Article
Bouzo-Lorenzo, M., Stoddart, L. A., Xia, L., Jerzman, A. P., Heitman, L. H., Briddon, S. J., & Hill, S. J. (2019). A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor. Purinergic Signalling, doi:10.1007/s11302-019-09650-9

There is a growing interest in understanding the binding kinetics of compounds that bind to G proteincoupled receptors prior to progressing a lead compound into clinical trials. The widely expressed adenosine A3 receptor (A3AR) has been implicated in... Read More