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Halofrax volcanii as immobilised whole cell biocatalyst: new applications for halophilic systems (2019)
Journal Article
Haque, R., Paradisi, F., & Allers, T. (2019). Halofrax volcanii as immobilised whole cell biocatalyst: new applications for halophilic systems. Applied Microbiology and Biotechnology, doi:10.1007/s00253-019-09725-y

Enzyme-mediated synthesis of pharmaceutical compounds is a ‘green’ alternative to traditional synthetic chemistry, and microbial engineering opens up the possibility of using whole cells as mini-factories. Whole-cell biocatalysis reduces cost by elim... Read More

Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential (2019)
Journal Article
Raghunathan, D., Radford, P. M., Gell, C., Negus, D., Moore, C., Till, R., …Tyson, J. (2019). Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential. Scientific Reports, 9, 1-16

In assessing the potential of predatory bacteria, such as Bdellovibrio bacteriovorus, to become live therapeutic agents against bacterial infections, it is crucial to understand and quantify Bdellovibrio host cell interactions at a molecular level. H... Read More

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a (2019)
Journal Article
Sanzà, P., Evans, R. D., Briggs, D. A., Cantero, M., Montoliu, L., Patel, S., …Hume, A. N. (in press). Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a. Journal of Cell Science,

Rab GTPases are compartment-specific molecular switches that regulate intracellular vesicular transport in eukaryotes. GDP/GTP exchange factors (GEFs) control Rab activation, and current models propose that localised and regulated GEF activity is imp... Read More

De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation (2019)
Journal Article
Ducker, C., Chow, L., Saxton, J., Handwerger, J., McGregor, A., Strahl, T., …Shaw, P. E. (2019). De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation. Nucleic Acids Research, doi:10.1093/nar/gkz166

ELK-1 is a transcription factor involved in ERK-induced cellular proliferation. Here we show that its transcriptional activity is modulated by ubiquitination at lysine 35 (K35). The level of ubiquitinated ELK-1 rises in mitogen-deprived cells and fal... Read More

Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification (2019)
Journal Article
Brown, A. M., Evans, R. D., Smith, P. A., Rich, L. R., & Ransom, B. R. (2019). Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification. Physiological Reports, 7(5), 1-13. doi:10.14814/phy2.14007

Hypoglycemia is a common iatrogenic consequence of type 1 diabetes therapy that can lead to central nervous system injury and even death if untreated. In the absence of clinically effective neuroprotective drugs we sought to quantify the putative neu... Read More

Immunological and pathological effects of e-cigarettes (2019)
Journal Article
Chen, I., Todd, I., & Fairclough, L. C. (in press). Immunological and pathological effects of e-cigarettes. Basic and Clinical Pharmacology and Toxicology,

Electronic cigarettes (E-cigarettes) are considered a preferable alternative to conventional cigarettes due to the lack of combustion and the absence of tobacco-specific toxicants. E-cigarettes have rapidly gained in popularity in recent years amongs... Read More

Discrete or indiscrete? Redefining the colour polymorphism of the land snail Cepaea nemoralis (2019)
Journal Article
Davison, A., Jackson, H. J., Murphy, E. W., & Reader, T. (2019). Discrete or indiscrete? Redefining the colour polymorphism of the land snail Cepaea nemoralis. Heredity, doi:10.1038/s41437-019-0189-z

Biologists have long tried to describe and name the different phenotypes that make up the shell polymorphism of the land snail Cepaea nemoralis. Traditionally, the view is that the ground colour of the shell is one of a few major colour classes, eith... Read More

The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer: a systematic review and meta-analysis (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer: a systematic review and meta-analysis. Annals of Surgery, doi:10.1097/SLA.0000000000003256

Objective: To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer. Summary background data: Although studies have shown that perioperative IMN... Read More

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations (2019)
Journal Article
Sakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., …Cho, M. H. (2019). Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations. Nature Genetics, doi:10.1038/s41588-018-0342-2

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide novel insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 control... Read More

Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa (2019)
Journal Article
Monnahan, P., Kolář, F., Baduel, P., Sailer, C., Koch, J., Horvath, R., …Yant, L. (2019). Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa. Nature Ecology and Evolution, 3, 457-468. doi:10.1038/s41559-019-0807-4

Ploidy-variable species allow direct inference of the effects of chromosome copy number on fundamental evolutionary processes. While an abundance of theoretical work suggests polyploidy should leave distinct population genomic signatures, empirical d... Read More

Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity (2019)
Journal Article
Holmes, J., Fairclough, L., & Todd, I. (2019). Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity. Archives of Dermatological Research, 1-22. doi:10.1007/s00403-019-01890-4

Atopic dermatitis (AD) is a widespread condition that appears to be increasing in prevalence and severity worldwide, yet the underlying mechanisms are not well understood. Recent research has identified various similarities between AD and autoimmune... Read More

Internal embryonic development in a non-copulatory, egg-laying teleost, the three-spined stickleback, Gasterosteus aculeatus (2019)
Journal Article
Dean, L. L., Robertson, S., Mahmud, M., & Maccoll, A. D. C. (2019). Internal embryonic development in a non-copulatory, egg-laying teleost, the three-spined stickleback, Gasterosteus aculeatus. Scientific Reports, 9, doi:10.1038/s41598-019-38584-w

The switch from egg-laying to retaining and giving birth to live young is a major transition in the history of life. Despite its repeated evolution across the fishes, records of intermediate phenotypes are vanishingly rare, with only two known cases... Read More

A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor (2019)
Journal Article
Bouzo-Lorenzo, M., Stoddart, L. A., Xia, L., Jerzman, A. P., Heitman, L. H., Briddon, S. J., & Hill, S. J. (in press). A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor. Purinergic Signalling,

There is a growing interest in understanding the binding kinetics of compounds that bind to G proteincoupled receptors prior to progressing a lead compound into clinical trials. The widely expressed adenosine A3 receptor (A3AR) has been implicated in... Read More

Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis (2019)
Journal Article
Ramos Gonzalez, D., Aramendia, A. C., & Davison, A. (2019). Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis. Heredity, doi:10.1038/s41437-019-0190-6

Although the land snail Cepaea nemoralis is one of the most thoroughly investigated colour polymorphic species, there have been few recent studies on the inheritance of the shell traits. Previously, it has been shown that the shell polymorphism is co... Read More

G protein-coupled receptors are dynamic regulators of digestion and targets for digestive diseases (2019)
Journal Article
Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L., Bunnett, N. W., & Bunnett, N. (2019). G protein-coupled receptors are dynamic regulators of digestion and targets for digestive diseases. Gastroenterology, doi:10.1053/j.gastro.2019.01.266

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neu... Read More