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The evidence for the effectiveness of safety alerts in electronic patient medication record systems at the point of pharmacy order entry: a systematic review (2013)
Journal Article
Ojeleye, O., Avery, A., Gupta, V., & Boyd, M. (2013). The evidence for the effectiveness of safety alerts in electronic patient medication record systems at the point of pharmacy order entry: a systematic review. BMC Medical Informatics and Decision Making, 13(July), Article 10. https://doi.org/10.1186/1472-6947-13-69

Background: Electronic Patient Medication Record (ePMR) systems have important safety features embedded to alert users about potential clinical hazards and errors. To date, there is no synthesis of evidence about the effectiveness of these safety fea... Read More about The evidence for the effectiveness of safety alerts in electronic patient medication record systems at the point of pharmacy order entry: a systematic review.

Specificity factors in cytoplasmic polyadenylation (2013)
Journal Article
Charlesworth, A., Meijer, H. A., & de Moor, C. H. (2013). Specificity factors in cytoplasmic polyadenylation. Wiley Interdisciplinary Reviews: RNA, 4(4), https://doi.org/10.1002/wrna.1171

Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been... Read More about Specificity factors in cytoplasmic polyadenylation.

Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1 (2013)
Journal Article
Hutter, V., Chau, D. Y., Hilgendorf, C., Brown, A., Cooper, A., Zann, V., …Bosquillon, C. (2014). Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 74-82. https://doi.org/10.1016/j.ejpb.2013.06.010

The impact of P-glycoprotein (MDR1, ABCB1) on drug disposition in the lungs as well as its presence and activity in in vitro respiratory drug absorption models remain controversial to date. Hence, we characterised MDR1 expression and the bidirectiona... Read More about Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1.

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor (2013)
Journal Article
Mistry, S. N., Valant, C., Sexton, P. M., Capuano, B., Christopoulos, A., & Scammells, P. J. (2013). Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. Journal of Medicinal Chemistry, 56(12), https://doi.org/10.1021/jm400540b

Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus. Adverse effects, due to indiscriminate... Read More about Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

Post-synthetic modification of conjugated microporous polymers (2013)
Journal Article
Ratvijitvech, T., Dawson, R., Laybourn, A., Khimyak, Y. Z., Adams, D. J., & Cooper, A. I. (2014). Post-synthetic modification of conjugated microporous polymers. Polymer, 55(1), 321-325. https://doi.org/10.1016/j.polymer.2013.06.004

Control over the surface functionality and microporosity in conjugated microporous polymers (CMPs) has been achieved by the post-synthetic modification of amines into amides of with different alkyl chains, one of which was chiral. The surface areas,... Read More about Post-synthetic modification of conjugated microporous polymers.

Delivery of definable number of drug or growth factor loaded poly(DL-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates (2013)
Journal Article
Qutachi, O., Shakesheff, K. M., & Buttery, L. D. (2013). Delivery of definable number of drug or growth factor loaded poly(DL-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates. Journal of Controlled Release, 168(1), https://doi.org/10.1016/j.jconrel.2013.02.029

Embryoid bodies (EBs) generated from embryonic stem cells are used to study processes of differentiation within a three dimensional (3D) cell environment. In many instances however, EBs are dispersed to single cell suspensions with a subsequent monol... Read More about Delivery of definable number of drug or growth factor loaded poly(DL-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates.

Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays (2013)
Journal Article
Hook, A. L., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D. G., …Alexander, M. R. (2013). Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials, 25(18), https://doi.org/10.1002/adma.201204936

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacteria... Read More about Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays.

Medicines use reviews: a potential resource or lost opportunity for general practice? (2013)
Journal Article
Latif, A., Pollock, K., & Boardman, H. F. (2013). Medicines use reviews: a potential resource or lost opportunity for general practice?. BMC Family Practice, 14, Article 57. https://doi.org/10.1186/1471-2296-14-57

Background: Patient non-adherence to medicines represents a significant waste of health resource and lost opportunity for health gain. Medicine management services are a key health policy strategy to encourage patients to take medicines as they are p... Read More about Medicines use reviews: a potential resource or lost opportunity for general practice?.

Synthesis and in vitro and in vivo characterization of highly ?1-Selective ?-Adrenoceptor partial agonists (2013)
Journal Article
Mistry, S. N., Baker, J. G., Fischer, P. M., Hill, S. J., Gardiner, S. M., & Kellam, B. (2013). Synthesis and in vitro and in vivo characterization of highly ?1-Selective ?-Adrenoceptor partial agonists. Journal of Medicinal Chemistry, 56(10), https://doi.org/10.1021/jm400348g

β-Adrenoceptor antagonists boast a 50-year use for symptomatic control in numerous cardiovascular diseases. One might expect highly selective antagonists are available for the human β-adrenoceptor subtype involved in these diseases, yet few truly β1-... Read More about Synthesis and in vitro and in vivo characterization of highly ?1-Selective ?-Adrenoceptor partial agonists.

Views and experiences of community pharmacists and superintendent pharmacists regarding the New Medicine Service in England prior to implementation (2013)
Journal Article
Wells, K. M., Thornley, T., Boyd, M. J., & Boardman, H. F. (2014). Views and experiences of community pharmacists and superintendent pharmacists regarding the New Medicine Service in England prior to implementation. Research in Social and Administrative Pharmacy, 10(1), https://doi.org/10.1016/j.sapharm.2013.03.003

Background: The New Medicine Service (NMS) was introduced to community pharmacies in England in October 2011. The NMS aims to improve adherence to new medicines in patients with selected long term conditions. The service consists of two follow-up con... Read More about Views and experiences of community pharmacists and superintendent pharmacists regarding the New Medicine Service in England prior to implementation.

D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors (2013)
Journal Article
Bay-Richter, C., O'Callaghan, M., Mathur, N., O'Tuathaigh, C., Heery, D., Fone, K. C., …Moran, P. (in press). D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors. Neuropsychopharmacology, 38(8), https://doi.org/10.1038/npp.2013.50

Drugs that induce psychosis, such as D-amphetamine (AMP), and those that alleviate it, such as antipsychotics, are suggested to exert behavioral effects via dopamine receptor D2 (D2). All antipsychotic drugs are D2 antagonists, but D2 antagonism und... Read More about D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors.

Cross-cultural adaptation of the short-form condom attitude scale: Validity assessment in a sub-sample of rural-to-urban migrant workers in Bangladesh (2013)
Journal Article
Roy, T., Anderson, C., Evans, C., Rahman, M. S., & Rahman, M. (2013). Cross-cultural adaptation of the short-form condom attitude scale: Validity assessment in a sub-sample of rural-to-urban migrant workers in Bangladesh. BMC Public Health, 13(1), https://doi.org/10.1186/1471-2458-13-240

Background: The reliable and valid measurement of attitudes towards condom use are essential to assist efforts to design population specific interventions aimed at promoting positive attitude towards, and increased use of condoms. Although several st... Read More about Cross-cultural adaptation of the short-form condom attitude scale: Validity assessment in a sub-sample of rural-to-urban migrant workers in Bangladesh.

PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs (2013)
Journal Article
Wadelin, F. R., Fulton, J., Collins, H. M., Tertipis, N., Bottley, A., Spriggs, K. A., …Heery, D. M. (2013). PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs. PLoS ONE, 8(2), Article e58052. https://doi.org/10.1371/journal.pone.0058052

Preferentially expressed antigen in melanoma (PRAME) has been described as a cancer-testis antigen and is associated with leukaemias and solid tumours. Here we show that PRAME gene transcription in leukaemic cell lines is rapidly induced by exposure... Read More about PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs.

The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower) (2013)
Journal Article
Furse, S., Liddell, S., Ortori, C. A., Williams, H., Neylon, D. C., Scott, D. J., …Gray, D. A. (2013). The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower). Journal of Chemical Biology, 6(2), 63-76. https://doi.org/10.1007/s12154-012-0090-1

In this paper we report the molecular profiling, lipidome and proteome, of the plant organelle known as an oil body (OB). The OB is remarkable in that it is able to perform its biological role (storage of triglycerides) whilst resisting the physical... Read More about The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower).

Tuning the mechanical properties of self-assembled mixed-peptide tubes (2013)
Journal Article
Sedman, V., Chen, X., Allen, S., Roberts, C., Korolkov, V., & Tendler, S. (2013). Tuning the mechanical properties of self-assembled mixed-peptide tubes. Journal of Microscopy, 249(3), https://doi.org/10.1111/jmi.12005

In this study, nano- and microscale fibrillar and tubular structures formed by mixing two aromatic peptides known to self-assemble separately, (diphenylalanine and di-D-2-napthylalanine) have been investigated. The morphology, mechanical strength and... Read More about Tuning the mechanical properties of self-assembled mixed-peptide tubes.

High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry (2013)
Journal Article
Hook, A. L., Scurr, D. J., Anderson, D. G., Langer, R., Williams, P., Davies, M. C., & Alexander, M. R. (2013). High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry. Surface and Interface Analysis, 45(1), https://doi.org/10.1002/sia.4910

Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discove... Read More about High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry.

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., …Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces (2012)
Journal Article
Epa, V., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., …Winkler, D. A. (2012). Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. Journal of Materials Chemistry, 39(22), https://doi.org/10.1039/C2JM34782B

Designing materials to control biology is an intense focus of biomaterials and regenerative medicine research. Discovering and designing materials with appropriate biological compatibility or active control of cells and tissues is being increasingly... Read More about Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces.

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), 868-875. https://doi.org/10.1038/nbt.2316

Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput... Read More about Combinatorial discovery of polymers resistant to bacterial attachment.