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Tuning the mechanical properties of self-assembled mixed-peptide tubes

Sedman, V.L.; Chen, X.; Allen, S.; Roberts, C.J.; Korolkov, V.V.; Tendler, S.J.B.

Authors

V.L. Sedman

X. Chen

S. Allen

C.J. Roberts

V.V. Korolkov

S.J.B. Tendler

Abstract

In this study, nano- and microscale fibrillar and tubular structures formed by mixing two aromatic peptides known to self-assemble separately, (diphenylalanine and di-D-2-napthylalanine) have been investigated. The morphology, mechanical strength and thermal stability of the tubular structures formed have been studied. The tubes are shown to consist of both peptides with some degree of nanoscale phase separation. The ability of the mixed peptides to form structures, which display variable mechanical properties dependent on the percentage composition of the peptides is presented. Such materials with tuneable properties will be required for a range of applications in nanotechnology and biotechnology.

Journal Article Type Article
Publication Date Jan 11, 2013
Journal Journal of Microscopy
Print ISSN 0022-2720
Electronic ISSN 0022-2720
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 249
Issue 3
Institution Citation Sedman, V., Chen, X., Allen, S., Roberts, C., Korolkov, V., & Tendler, S. (2013). Tuning the mechanical properties of self-assembled mixed-peptide tubes. Journal of Microscopy, 249(3), doi:10.1111/jmi.12005
DOI https://doi.org/10.1111/jmi.12005
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/jmi.12005/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0




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