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Combinatorial discovery of polymers resistant to bacterial attachment

Hook, Andrew L.; Chang, Chien-Yi; Yang, Jing; Luckett, Jeni; Cockayne, Alan; Atkinson, Steve; Mei, Ying; Bayston, Roger; Irvine, Derek J.; Langer, Robert; Anderson, Daniel G.; Williams, Paul; Davies, Martyn C.; Alexander, Morgan R.

Authors

Andrew L. Hook

Chien-Yi Chang

Jing Yang

Jeni Luckett

Alan Cockayne

Steve Atkinson

Ying Mei

Roger Bayston roger.bayston@nottingham.ac.uk

Derek J. Irvine

Robert Langer

Daniel G. Anderson

Paul Williams

Martyn C. Davies

Morgan R. Alexander Morgan.Alexander@nottingham.ac.uk

Abstract

Bacterial attachment and subsequent biofilm formation are key challenges to the long term performance of many medical devices. Here, a high throughput approach coupled with the analysis of surface structure-property relationships using a chemometics approach has been developed to simultaneously investigate the interaction of bacteria with hundreds of polymeric materials on a microarray format. Using this system, a new group of materials comprising ester and hydrophobic moieties are identified that dramatically reduce the attachment of clinically relevant, pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and uropathogenic Escherichia coli). Hit materials coated on silicone catheters resulted in up to a 30 fold reduction in coverage compared to a commercial silver embedded catheter, which has been proven to half the incidence of clinically acquired infection. These polymers represent a new class of materials resistant to bacterial attachment that could not have been predicted from the current understanding of bacteria-surface interactions.

Journal Article Type Article
Publication Date Aug 12, 2012
Journal Nature Biotechnology
Print ISSN 1087-0156
Electronic ISSN 1546-1696
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 30
Issue 9
Institution Citation Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), doi:10.1038/nbt.2316
DOI https://doi.org/10.1038/nbt.2316
Keywords Bacterial Adhesion, Biomedical Materials, Polymer Synthesis
Publisher URL http://www.nature.com/nbt/journal/v30/n9/full/nbt.2316.html
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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