All Outputs (130)

Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells (2017)
Journal Article
Gulfam, M., Matini, T., Monteiro, P. F., Riva, R., Collins, H., Spriggs, K., …Alexander, C. (2017). Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells. Biomaterials Science, 5, https://doi.org/10.1039/c6bm00888g

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we have synthesized a functional biodegradable and... Read More about Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells.

Quality control of a medicinal larval (Lucilia sericata) debridement device based on released gelatinase activity (2017)
Journal Article
Pickles, S., & Pritchard, D. I. (2017). Quality control of a medicinal larval (Lucilia sericata) debridement device based on released gelatinase activity. Medical and Veterinary Entomology, 31(2), 200-206. https://doi.org/10.1111/mve.12220

Lucilia sericata Meigen (Diptera: Calliphoridae) larvae are manufactured worldwide for the treatment of chronic wounds. Published research has confirmed that the primary clinical effect of the product, debridement (the degradation of non-viable wound... Read More about Quality control of a medicinal larval (Lucilia sericata) debridement device based on released gelatinase activity.

Cell death mechanisms in tumoral and non-tumoral human cell lines triggered by photodynamic treatments: apoptosis, necrosis and parthanatos (2017)
Journal Article
Soriano, J., Mora-Espí, I., Alea-Reyes, M. E., Pérez-García, L., Barrios, L., Ibáñez, E., & Nogués, C. (2017). Cell death mechanisms in tumoral and non-tumoral human cell lines triggered by photodynamic treatments: apoptosis, necrosis and parthanatos. Scientific Reports, 7, Article 41340. https://doi.org/10.1038/srep41340

Cell death triggered by photodynamic therapy can occur through different mechanisms: apoptosis, necrosis or autophagy. However, recent studies have demonstrated the existence of other mechanisms with characteristics of both necrosis and apoptosis. Th... Read More about Cell death mechanisms in tumoral and non-tumoral human cell lines triggered by photodynamic treatments: apoptosis, necrosis and parthanatos.

Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway (2017)
Journal Article
Castresana, J. S., Soo, H., Chung, F. F., Lim, K., Yap, V. A., Bradshaw, T. D., …Mai, C. (2017). Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway. PLoS ONE, 12(1), Article e0170551. https://doi.org/10.1371/journal.pone.0170551

Cudraflavone C (Cud C) is a naturally-occurring flavonol with reported anti-proliferative activities. However, the mechanisms by which Cud C induced cytotoxicity have yet to be fully elucidated. Here, we investigated the effects of Cud C on cell prol... Read More about Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway.

Surface modification of PdlLGA microspheres with gelatine methacrylate: evaluation of adsorption, entrapment, and oxygen plasma treatment approaches (2017)
Journal Article
Baki, A., Rahman, C. V., White, L. J., Scurr, D. J., Qutachi, O., & Shakesheff, K. M. (2017). Surface modification of PdlLGA microspheres with gelatine methacrylate: evaluation of adsorption, entrapment, and oxygen plasma treatment approaches. Acta Biomaterialia, 53, 450-459. https://doi.org/10.1016/j.actbio.2017.01.042

Injectable poly (dl-lactic-co-glycolic acid) (PdlLGA) microspheres are promising candidates as biodegradable controlled release carriers for drug and cell delivery applications; however, they have limited functional groups on the surface to enable de... Read More about Surface modification of PdlLGA microspheres with gelatine methacrylate: evaluation of adsorption, entrapment, and oxygen plasma treatment approaches.

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity (2017)
Journal Article
Taha, D. A., Zgair, A., Lee, J. B., de Moor, C. H., Barrett, D. A., Bruce, K. D., …Gershkovich, P. (2017). Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity. European Journal of Pharmaceutical Sciences, 100, 163-175. https://doi.org/10.1016/j.ejps.2017.01.018

The association of lipophilic statins with plasma lipoproteins in the presence of disturbed acid-base balance can modify the pharmacokinetics and tissue distribution of these drugs, resulting in alteration in their efficacy and toxicity profiles. The... Read More about Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity.

Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays (2017)
Journal Article
Lee, J. B., Zgair, A., Taha, D. A., Zang, X., Kagan, L., Kim, T. H., …Gershkovich, P. (2017). Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays. European Journal of Pharmaceutics and Biopharmaceutics, 114, 38-42. https://doi.org/10.1016/j.ejpb.2016.12.027

In this study, Caco-2 permeability results from different laboratories were compared. Six different sets of apparent permeability coefficient (Papp) values reported in the literature were compared to experimental Papp obtained in our laboratory. The... Read More about Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays.

Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis (2017)
Journal Article
Janknegt, R., van den Beuken, M., Schiere, S., Überall, M., Knaggs, R., Hanley, J., & Thronaes, M. (in press). Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis. European Journal of Hospital Pharmacy, 25(3), https://doi.org/10.1136/ejhpharm-2016-001127

Drug selection of rapid acting fentanyl formulations in the treatment of breakthrough pain in patients with cancer is performed by the System of Objectified Judgement Analysis method. All seven available formulations were included in the analysis. Th... Read More about Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis.

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation (2017)
Journal Article
Ivanov, I., Matafonov, A., Sun, M., Cheng, Q., Dickeson, S. K., Verhamme, I. M., …Gailani, D. (2017). Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation. Blood, 129(11), 1527-1537. https://doi.org/10.1182/blood-2016-10-744110

When blood is exposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the proteases αFXIIa and α-kallikrein by a process called contact ac... Read More about Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation.

Social media in health science education: an international survey (2017)
Journal Article
O'Sullivan, E., Cutts, E., Kavikondala, S., Salcedo, A., D'Souza, K., Hernandez-Torre, M., …Last, J. (2017). Social media in health science education: an international survey. JMIR Medical Education, 3(1), https://doi.org/10.2196/mededu.6304

Background: Social media is an asset that higher education students can use for an array of purposes. Studies have shown the merits of social media use in educational settings; however, its adoption in health science education has been slow, and the... Read More about Social media in health science education: an international survey.