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Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis

Janknegt, Robert; van den Beuken, Marieke; Schiere, Sjouke; Überall, Michael; Knaggs, Roger; Hanley, Jaquie; Thronaes, Morten

Authors

Robert Janknegt

Marieke van den Beuken

Sjouke Schiere

Michael Überall

Roger Knaggs

Jaquie Hanley

Morten Thronaes



Abstract

Drug selection of rapid acting fentanyl formulations in the treatment of breakthrough pain in patients with cancer is performed by the System of Objectified Judgement Analysis method. All seven available formulations were included in the analysis. The following selection criteria were used: number of available strengths, variability in the rate of absorption, interactions, clinical efficacy, side effects, ease of administration and documentation. No direct double-blind comparative studies between two or more formulations were identified and the clinical documentation of all formulations is limited. The most distinguishing criterion was ease of use. This led to slightly higher scores for Abstral, Instanyl and PecFent than for the other formulations. The pros and cons of each formulation should be discussed with the patient, and the most suitable formulation selected for each individual patient.

Journal Article Type Article
Journal European Journal of Hospital Pharmacy
Print ISSN 2047-9956
Electronic ISSN 2047-9964
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 25
Issue 3
APA6 Citation Janknegt, R., van den Beuken, M., Schiere, S., √úberall, M., Knaggs, R., Hanley, J., & Thronaes, M. (in press). Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis. European Journal of Hospital Pharmacy, 25(3), https://doi.org/10.1136/ejhpharm-2016-001127
DOI https://doi.org/10.1136/ejhpharm-2016-001127
Publisher URL http://ejhp.bmj.com/content/early/2017/01/11/ejhpharm-2016-001127
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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