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Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function (2014)
Journal Article
Chen, L., Tang, W., Kowgier, M., Loth, D. W., Soler Artigas, M., Joubert, B. R., …Cassano, P. A. (2014). Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function. PLoS ONE, 9(7), Article e100776. https://doi.org/10.1371/journal.pone.0100776

Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. Methods: We performed GWAS of the rate of cha... Read More about Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function.

Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's Disease (2014)
Journal Article
Laughton, C., Mazanetz, M., & Fischer, P. (2014). Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's Disease. Molecules, 19(7), 9134-9159. https://doi.org/10.3390/molecules19079134

The pathological characteristics of Alzheimer’s Disease (AD) have been linked to the activity of three particular kinases—Glycogen Synthase Kinase 3β (GSK3β), Cyclin-Dependent Kinase 5 (CDK5) and Extracellular-signal Regulated Kinase 2 (ERK2). As a c... Read More about Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's Disease.

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article
Morris, G., Bridge, J., Eltboli, O., Lewis, M., Knox, A., Aylott, J. W., …Rose, F. R. (2014). Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. AJP - Lung Cellular and Molecular Physiology, 307(1), Article L38-L47. https://doi.org/10.1152/ajplung.00318.2013

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.

High throughput screening for biomaterials discovery (2014)
Journal Article
Algahtani, M. S., Alexander, M., Scurr, D. J., Hook, A. L., Anderson, D. G., Langer, R. S., …Davies, M. C. (2014). High throughput screening for biomaterials discovery. Journal of Controlled Release, 190, 115-126. https://doi.org/10.1016/j.jconrel.2014.06.045

Using microarray technologies thousands of biomedical materials can be screened in a rapid, parallel and cost effective fashion to identify the optimum candidate that fulfils a specific biomedical application. High throughput surface characterization... Read More about High throughput screening for biomaterials discovery.

Comparing women pharmacy consumers’ experiences with weight loss treatment in Victoria and Nottingham: a cross-sectional study (2014)
Journal Article
Boardman, H., Fakih, S., Marriott, J. L., Anderson, C., & Hussainy, S. Y. (2014). Comparing women pharmacy consumers’ experiences with weight loss treatment in Victoria and Nottingham: a cross-sectional study. BMC Public Health, 14, 1-12. https://doi.org/10.1186/1471-2458-14-662

Background: There has been a recent increase in weight management services available in pharmacies across Australia and England. The aim of this study was to determine the following between women in Victoria and Nottingham: similarities and differenc... Read More about Comparing women pharmacy consumers’ experiences with weight loss treatment in Victoria and Nottingham: a cross-sectional study.

Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide (2014)
Journal Article
Korolkov, V. V., Svatek, S. A., Allen, S., Roberts, C. J., Tendler, S. J., Taniguchi, T., …Beton, P. H. (2014). Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide. Chemical Communications, 50(64), https://doi.org/10.1039/C4CC03720K

A two-dimensional porous network formed from perylene tetracarboxylic diimide (PTCDI) and melamine may be deposited from solution on the surfaces of highly oriented pyrolytic graphite (HOPG), hexagonal boron nitride (hBN) and molybdenum disulphide (... Read More about Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide.

Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model (2014)
Journal Article
Smith, E., Rose, F., Kanczler, J., Shakesheff, K., Gothard, D., White, L., …Oreffoa, R. (2014). Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4186-4196. https://doi.org/10.1016/j.actbio.2014.06.011

Current clinical treatments for skeletal conditions resulting in large-scale bone loss include autograft or allograft, both of which have limited effectiveness. In seeking to address bone regeneration, several tissue engineering strategies have come... Read More about Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model.

A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells (2014)
Journal Article
Morris, G., Bridge, J., Brace, L., Knox, A., Aylott, J. W., Brightling, C., …Rose, F. R. (2014). A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells. Biofabrication, 6(3), Article 035014. https://doi.org/10.1088/1758-5082/6/3/035014

Conventional airway in vitro models focus upon the function of individual structural cells cultured in a two-dimensional monolayer, with limited three-dimensional (3D) models of the bronchial mucosa. Electrospinning offers an attractive method to pro... Read More about A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells.

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth (2014)
Journal Article
McLaren, J. S., Bayston, R., White, L. J., Cox, H. C., Ashraf, W., Rahman, C. V., …Scammell, B. E. (2014). A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth. eCells and Materials Journal, 27, 332-349. https://doi.org/10.22203/eCM.v027a24

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More about A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth.

Real time Raman imaging to understand dissolution performance of amorphous solid dispersions (2014)
Journal Article
Tres, F., Treacher, K., Booth, J., Hughes, L. P., Wren, S. A., Aylott, J. W., & Burley, J. C. (2014). Real time Raman imaging to understand dissolution performance of amorphous solid dispersions. Journal of Controlled Release, 188, https://doi.org/10.1016/j.jconrel.2014.05.061

We have employed for the first time Raman spectroscopic imaging along with multi-variate curve resolution (MCR) analysis to investigate in real time and in-situ the dissolution mechanisms that underpin amorphous solid dispersions, with data being col... Read More about Real time Raman imaging to understand dissolution performance of amorphous solid dispersions.

Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling (2014)
Journal Article
Hong, W., Laughton, C. A., Li, J., Yap, L. F., Paterson, I. C., & Wang, H. (2014). Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling. Journal of Molecular Graphics and Modelling, 51, 193-202. https://doi.org/10.1016/j.jmgm.2014.05.010

Protein arginine methyltransferases (PRMTs) catalyse the methylation of arginine residues of target proteins. PRMTs utilise S-adenosyl methionine (SAM) as the methyl group donor, leading to S-adenosyl homocysteine (SAH) and monomethylarginine (mMA).... Read More about Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling.

Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model (2014)
Journal Article
Smith, E., Felicity, R., Kanczler, J., Shakesheff, K., Gothard, D., White, L., …Oreffoa, R. (2014). Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4197-4205. https://doi.org/10.1016/j.actbio.2014.05.025

There is an unmet need for improved, effective tissue engineering strategies to replace or repair bone damaged through disease or injury. Recent research has focused on developing biomaterial scaffolds capable of spatially and temporally releasing co... Read More about Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model.

Materials for stem cell factories of the future (2014)
Journal Article
Celiz, A. D., Smith, J. G., Langer, R., Anderson, D. G., Barrett, D. A., Winkler, D. A., …Alexander, M. R. (2014). Materials for stem cell factories of the future. Nature Materials, 13(6), 570-579. https://doi.org/10.1038/nmat3972

The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking a... Read More about Materials for stem cell factories of the future.

Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling (2014)
Journal Article
Magennis, E. P., Fernandez-Trillo, F., Sui, C., Spain, S. G., Bradshaw, D., Churchley, D., …Alexander, C. (2014). Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nature Materials, 13(7), 748-755. https://doi.org/10.1038/nmat3949

The detection and inactivation of pathogenic strains of bacteria continues to be an important therapeutic goal. Hence, there is a need for materials that can bind selectively to specific microorganisms for diagnostic or anti-infective applications, b... Read More about Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling.

Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase (2014)
Journal Article
Moses, J. E., Harper, S., Dempster, S., Dreveny, I., Harper, S., & Moses, J. (2014). Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase. Acta Crystallographica Section D: Biological Crystallography, 70(5), 1484-1490. https://doi.org/10.1107/s1399004714005422

Lactate dehydrogenase A (LDH-A) is a key enzyme in anaerobic respiration that is predominantly found in skeletal muscle and catalyses the reversible conversion of pyruvate to lactate in the presence of NADH. LDH-A is overexpressed in many tumours and... Read More about Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.

New insights into electrocatalysis based on plasmon resonance for the real-time monitoring of catalytic events on single gold nanorods (2014)
Journal Article
Jing, C., Rawson, F. J., Zhou, H., Shi, X., Li, W., Li, D., & Long, Y. (2014). New insights into electrocatalysis based on plasmon resonance for the real-time monitoring of catalytic events on single gold nanorods. Analytical Chemistry, 86(11), 5513-5518. doi:10.1021/ac500785u

Gold nanoparticles (GNPs) have been widely applied in industrial catalysis and electrocatalysis. Owing to their wide variety of shapes, sizes, and compositions, a range of different catalytic properties is possible. Thus, it is important to monitor c... Read More about New insights into electrocatalysis based on plasmon resonance for the real-time monitoring of catalytic events on single gold nanorods.

Illustrating the interplay between the extracellular matrix and microRNAs (2014)
Journal Article
Piccinini, A. M., & Midwood, K. S. (2014). Illustrating the interplay between the extracellular matrix and microRNAs. International Journal of Experimental Pathology, 95(3), (158-180). doi:10.1111/iep.12079. ISSN 0959-9673

The discovery of cell surface receptors that bind to extracellular matrix (ECM) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extra... Read More about Illustrating the interplay between the extracellular matrix and microRNAs.