All Outputs (13)

Development of dual anti-biofilm and anti-bacterial medical devices (2020)
Journal Article

The rising occurrence of antimicrobial resistance demands new strategies for delivering antibiotics to ensure their effective use. In this study, a multi-functional strategy to address medical device associated infections is explored whereby an anti-... Read More about Development of dual anti-biofilm and anti-bacterial medical devices.

Comment on: Durability of antimicrobial activity of antibiotic-impregnated external ventricular drains: a prospective study (2020)
Journal Article

Comment on: Durability of antimicrobial activity of antibiotic-impregnated external ventricular drains: a prospective study (2019)
Journal Article

Propidium Monoazide -Polymerase Chain Reaction for Detection of Residual Periprosthetic Joint Infection in Two-Stage Revision (2019)
Journal Article

Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane (2019)
Journal Article

© 2019, The Author(s). Amniotic membrane (AM) is used to treat a range of ophthalmic indications but must be presented in a non-contaminated state. AM from elective caesarean sections contains natural microbial contamination, requiring removal during... Read More about Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane.

An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study (2019)
Journal Article

© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. BACKGROUND: External ventricular drainage (EVD) carries a high risk of ventriculitis, increasingly caused by MDR Gram-negative... Read More about An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study.

An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks (2019)
Journal Article

Two major complications of indwelling urinary catheterisation include infection and mineral encrustation of the catheter. Our antimicrobial urinary catheter (AUC) impregnated with rifampicin, triclosan, and sparfloxacin has demonstrated long-term pro... Read More about An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks.

Comparison of different human tissue processing methods for maximization of bacterial recovery (2018)
Journal Article

Tissues are valuable microbiological samples that have proved superiority over swabs. Culture of tissue samples is used in the diagnosis of a variety of infections. However, as well as factors such as the site of obtaining the sample, the number of s... Read More about Comparison of different human tissue processing methods for maximization of bacterial recovery.

Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis? (2015)
Journal Article

OBJECT Recently concern has arisen over the effect of released antimicrobial agents from antibiotic-impregnated external ventricular drainage (EVD) catheters on the reliability of CSF culture for diagnosis of ventriculitis. The authors designed a... Read More about Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis?.

Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity (2015)
Journal Article

© 2015 Published by Elsevier B.V. Catheter-associated urinary tract infection (CAUTI) is the commonest hospital-acquired infection, accounting for over 100,000 hospital admissions within the USA annually. Biomaterials and processes intended to reduce... Read More about Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity.

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model (2014)
Journal Article

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More about A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model.

Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro (2012)
Journal Article

Cerebrospinal fluid (CSF) shunts used to treat hydrocephalus have an overall infection rate of about 10% of operations. The commonest causative bacteria are Staphylococcus epidermidis, followed by Staphylococcus aureus and enterococci. Major difficul... Read More about Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro.

Activity of an antimicrobial hydrocephalus shunt catheter against Propionibacterium acnes (2010)
Journal Article

Shunt infection is a major complication affecting approximately 10% of procedures. Propionibacterium acnes, an anaerobic skin bacterium, is increasingly recognized as a shunt pathogen, causing up to 14% of infections. Though susceptible to penicillin... Read More about Activity of an antimicrobial hydrocephalus shunt catheter against Propionibacterium acnes.