All Outputs (40)

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands (2015)
Journal Article

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Bas... Read More about The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands.

Concentrating tripartite quantum information (2015)
Journal Article

We introduce the concentrated information of tripartite quantum states. For three parties Alice, Bob, and Charlie, it is defined as the maximal mutual information achievable between Alice and Charlie via local operations and classical communication p... Read More about Concentrating tripartite quantum information.

Homotopy colimits and global observables in Abelian gauge theory (2015)
Journal Article

We study chain complexes of field configurations and observables for Abelian gauge theory on contractible manifolds, and show that they can be extended to non-contractible manifolds by using techniques from homotopy theory. The extension prescription... Read More about Homotopy colimits and global observables in Abelian gauge theory.

BJP is linking its articles to the IUPHAR/BPS Guide to PHARMACOLOGY (2015)
Journal Article

Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells (2015)
Journal Article

© 2015 The Authors. Aims: To investigate the regulation of cannabinoid receptors CB1 and CB2 on immune cells by pro-inflammatory cytokines and its potential relevance to the inflammatory neurological disease, multiple sclerosis (MS). CB1 and CB2 sign... Read More about Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

A potential role for cannabinoid receptors in the therapeutic action of fenofibrate (2014)
Journal Article

Cannabinoids are reported to have actions through peroxisome proliferator-activated receptors (PPARs), which led us to investigate PPAR agonists for activity at the cannabinoid receptors. Radio-ligand binding and functional assays were conducted usin... Read More about A potential role for cannabinoid receptors in the therapeutic action of fenofibrate.

Effects of NAD at purine receptors in isolated blood vessels (2014)
Journal Article

Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles. However, there is evidence that they can also be released from cells to act as novel extrace... Read More about Effects of NAD at purine receptors in isolated blood vessels.

A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries (2014)
Journal Article

Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolar-ization (EDH) and EDH may act as a ‘back up’ system to compensate the loss of the NO pathway. Here,the mechanism of action of H2O2in porcine isolated cor... Read More about A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.

The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes (2014)
Journal Article

Background: Circulating endocannabinoid levels are increased in obesity and diabetes. We have shown that fatty acid amide hydrolase (FAAH, an endocannabinoid hydrolysing enzyme) in subcutaneous adipose tissue positively correlates with BMI in healthy... Read More about The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes.

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat (2014)
Journal Article

Rationale: Schizophrenia is a debilitating disorder comprising positive, negative and cognitive deficits with a poorly defined neurobiological aetiology; therefore, animal models with greater translational reliability are essential to develop improve... Read More about Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat.

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands (2013)
Journal Article

The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional... Read More about The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands.

A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition (2013)
Journal Article

Memories are believed to be represented in the synaptic pathways of vastly interconnected networks of neurons. The plasticity of synapses, that is, their strengthening and weakening depending on neuronal activity, is believed to be the basis of lea... Read More about A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition.

Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems (2012)
Journal Article

In this article, we highlight an issue that arises when using multiple b?values in a model?based analysis of diffusion MR data for tractography. The non?monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in... Read More about Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems.

Fundamental properties of Ca²⁺ signals (2011)
Journal Article

Background Ca²⁺ is a ubiquitous and versatile second messenger that transmits information through changes of the cytosolic Ca²⁺ concentration. Recent investigations changed basic ideas on the dynamic character of Ca²⁺ signals and challenge tradition... Read More about Fundamental properties of Ca²⁺ signals.

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain (2010)
Journal Article

Objective. To investigate the impact of an experimental model of osteoarthritis (OA) on spinal nociceptive processing and the role of the inhibitory endocannabinoid system in regulating sensory processing at the spinal level. Methods. Experiment... Read More about Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain.

Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo (2006)
Journal Article

In this study, we have used the selective A2A adenosine receptor antagonist KW6002 to investigate the function of A2A receptors in the Lister hooded rat nucleus accumbens in vitro and in vivo. Radioligand binding studies confirmed a greater than 50-f... Read More about Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo.

A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening (2005)
Journal Article

Signalling via the endocannabinoids anandamide and 2-arachidonylglycerol appears to be terminated largely through the action of the enzyme fatty acid amide hydrolase (FAAH). In this report, we describe a simple spectrophotometric assay to detect FAAH... Read More about A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening.

The cellular localization of adenosine receptors in rat neostriatum (1989)
Journal Article

Using quantitative autoradiography of ligand binding sites combined with lesions of specific neuronal pathways, the cellular locations of A1 and A2 adenosine receptors, as well as a third binding site for the adenosine receptor ligand, [3H]N-ethylcar... Read More about The cellular localization of adenosine receptors in rat neostriatum.

Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography (1982)
Journal Article

Chromatographic retention and peak shapes for a group of five 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography have been examined with a series of eluents containing various amines as part of the buffer system. An ODS... Read More about Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography.

Group-contribution approach to the behaviour of 2-phenyl-ethylamines in reversed-phase high-performance liquid chromatography (1981)
Journal Article

High-performance liquid chromatography retention data are reported for 2-phenylethylamine and 30 of its derivatives, including examples of CH3 OH, OCH3, COOH, NH2 and N-oxide substitution. An octadecyl-silica column was used with an eluent of 10% met... Read More about Group-contribution approach to the behaviour of 2-phenyl-ethylamines in reversed-phase high-performance liquid chromatography.