Group-contribution approach to the behaviour of 2-phenyl-ethylamines in reversed-phase high-performance liquid chromatography

Gill, R.; Alexander, S. P.; Moffat, A. C.

Abstract

High-performance liquid chromatography retention data are reported for 2-phenylethylamine and 30 of its derivatives, including examples of CH3 OH, OCH3, COOH, NH2 and N-oxide substitution. An octadecyl-silica column was used with an eluent of 10% methanol containing an amine-phosphate buffer (pH 3.15) to limit the interference of the silica support with chromatographic retention. The effects of individual substituents on retention are quantified by using group-contribution values (τ) and are discussed with reference to the position of substitution and the intramolecular interactions with other groups. © 1981.

Citation

Gill, R., Alexander, S. P., & Moffat, A. C. (1981). Group-contribution approach to the behaviour of 2-phenyl-ethylamines in reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 218(C), 639-646. https://doi.org/10.1016/S0021-9673%2800%2982089-0

• Journal Article Type: Article
• Online Publication Date: Nov 1, 2001
• Publication Date: Nov 20, 1981
• Deposit Date: Dec 3, 2022
• Journal: Journal of Chromatography A
• Print ISSN: 0021-9673
• Electronic ISSN: 1873-3778
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 218
• Issue: C
• Pages: 639-646
• DOI: https://doi.org/10.1016/S0021-9673%2800%2982089-0
• Public URL: https://nottingham-repository.worktribe.com/output/14322357
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0021967300820890?via%3Dihub