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The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

Pawson, Adam J.; Sharman, Joanna L.; Benson, Helen E.; Faccenda, Elena; Alexander, Stephen P.H.; Buneman, O. Peter; Davenport, Anthony P.; McGrath, John C.; Peters, John A.; Southan, Christopher; Spedding, Michael; Yu, Wenyuan; Harmar, Anthony J.

Authors

Adam J. Pawson

Joanna L. Sharman

Helen E. Benson

Elena Faccenda

Stephen P.H. Alexander Steve.Alexander@nottingham.ac.uk

O. Peter Buneman

Anthony P. Davenport

John C. McGrath

John A. Peters

Christopher Southan

Michael Spedding

Wenyuan Yu

Anthony J. Harmar



Abstract

The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS 'Guide to Receptors and Channels' (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the approximately 6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques

Journal Article Type Article
Publication Date Jan 1, 2014
Journal Nucleic Acids Research
Print ISSN 0305-1048
Electronic ISSN 1362-4962
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 42
Issue D1
Article Number D1098-D1106
APA6 Citation Pawson, A. J., Sharman, J. L., Benson, H. E., Faccenda, E., Alexander, S. P., Buneman, O. P., …Harmar, A. J. (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Research, 42(D1), doi:10.1093/nar/gkt1143
DOI https://doi.org/10.1093/nar/gkt1143
Publisher URL http://nar.oxfordjournals.org/content/42/D1/D1098.short
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information © The Author(s) 2013. Published by Oxford University Press.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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