Adam J. Pawson
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
Pawson, Adam J.; Sharman, Joanna L.; Benson, Helen E.; Faccenda, Elena; Alexander, Stephen P.H.; Buneman, O. Peter; Davenport, Anthony P.; McGrath, John C.; Peters, John A.; Southan, Christopher; Spedding, Michael; Yu, Wenyuan; Harmar, Anthony J.
Authors
Joanna L. Sharman
Helen E. Benson
Elena Faccenda
STEPHEN ALEXANDER steve.alexander@nottingham.ac.uk
Associate Professor
O. Peter Buneman
Anthony P. Davenport
John C. McGrath
John A. Peters
Christopher Southan
Michael Spedding
Wenyuan Yu
Anthony J. Harmar
Abstract
The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS 'Guide to Receptors and Channels' (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the approximately 6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques
Citation
Pawson, A. J., Sharman, J. L., Benson, H. E., Faccenda, E., Alexander, S. P., Buneman, O. P., …Harmar, A. J. (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Research, 42(D1), Article D1098-D1106. https://doi.org/10.1093/nar/gkt1143
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 24, 2013 |
Online Publication Date | Nov 14, 2013 |
Publication Date | Jan 1, 2014 |
Deposit Date | Oct 31, 2016 |
Publicly Available Date | Mar 28, 2024 |
Journal | Nucleic Acids Research |
Print ISSN | 0305-1048 |
Electronic ISSN | 1362-4962 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 42 |
Issue | D1 |
Article Number | D1098-D1106 |
DOI | https://doi.org/10.1093/nar/gkt1143 |
Public URL | https://nottingham-repository.worktribe.com/output/720021 |
Publisher URL | http://nar.oxfordjournals.org/content/42/D1/D1098.short |
Additional Information | © The Author(s) 2013. Published by Oxford University Press. |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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