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Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography

Gill, R.; Alexander, S. P.; Moffat, A. C.

Authors

R. Gill

A. C. Moffat



Abstract

Chromatographic retention and peak shapes for a group of five 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography have been examined with a series of eluents containing various amines as part of the buffer system. An ODS-silica column was used with aqueous methanolic eluents containing orthophosphoric acid and sodium hydroxide to which the appropriatre amines were added. Eleven eluents containing different amines have been examined along with two control eluents containing only inorganic buffer components. Large improvements in peak shape are demonstrated by the addition of some amines. The importance of selecting amines of suitable hydrophobic character and molecular geometry is discussed. © 1982.

Journal Article Type Article
Online Publication Date Jan 18, 2002
Publication Date Sep 24, 1982
Deposit Date Dec 3, 2022
Journal Journal of Chromatography A
Print ISSN 0021-9673
Electronic ISSN 1873-3778
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 247
Issue 1
Pages 39-45
DOI https://doi.org/10.1016/S0021-9673%2800%2984854-2
Public URL https://nottingham-repository.worktribe.com/output/14322353
Publisher URL https://www.sciencedirect.com/science/article/abs/pii/S0021967300848542?via%3Dihub