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The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Southan, Christopher; Sharman, Joanna L.; Benson, Helen E.; Faccenda, Elena; Pawson, Adam J.; Alexander, Stephen P.H.; Buneman, O. Peter; Davenport, Anthony P.; McGrath, John C.; Peters, John A.; Spedding, Michael; Catterall, William A.; Fabbro, Doriano; Davies, Jamie A.

Authors

Christopher Southan

Joanna L. Sharman

Helen E. Benson

Elena Faccenda

Adam J. Pawson

Stephen P.H. Alexander Steve.Alexander@nottingham.ac.uk

O. Peter Buneman

Anthony P. Davenport

John C. McGrath

John A. Peters

Michael Spedding

William A. Catterall

Doriano Fabbro

Jamie A. Davies



Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options.

Journal Article Type Article
Publication Date Jan 4, 2016
Journal Nucleic Acids Research
Print ISSN 0305-1048
Electronic ISSN 1362-4962
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 44
Issue D1
Article Number D1054-D1068
APA6 Citation Southan, C., Sharman, J. L., Benson, H. E., Faccenda, E., Pawson, A. J., Alexander, S. P., …Davies, J. A. (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Research, 44(D1), doi:10.1093/nar/gkv1037
DOI https://doi.org/10.1093/nar/gkv1037
Publisher URL http://nar.oxfordjournals.org/content/44/D1/D1054
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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