All Outputs (37)

ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana (2023)
Journal Article

Oxygen is a key signalling component of plant biology, and whilst an oxygen-sensing mechanism was previously described in Arabidopsis thaliana, key features of the associated PLANT CYSTEINE OXIDASE (PCO) N-degron pathway and Group VII ETHYLENE RESPON... Read More about ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana.

A phloem‐localized Arabidopsis metacaspase (AtMC3) improves drought tolerance (2023)
Journal Article

Increasing drought phenomena pose a serious threat to agricultural productivity. Although plants have multiple ways to respond to the complexity of drought stress, the underlying mechanisms of stress sensing and signaling remain unclear. The role of... Read More about A phloem‐localized Arabidopsis metacaspase (AtMC3) improves drought tolerance.

An oxygen-sensing mechanism for angiosperm adaptation to altitude (2022)
Journal Article

Flowering plants (angiosperms) can grow at extreme altitudes, and have been observed growing as high as 6,400 metres above sea level1,2; however, the molecular mechanisms that enable plant adaptation specifically to altitude are unknown. One distingu... Read More about An oxygen-sensing mechanism for angiosperm adaptation to altitude.

Allelic shift in cis-elements of the transcription factor RAP2.12 underlies adaptation associated with humidity in Arabidopsis thaliana (2022)
Journal Article

Populations of widespread species are usually geographically distributed through contrasting stresses, but underlying genetic mechanisms controlling this adaptation remain largely unknown. Here, we show that in Arabidopsis thaliana, allelic changes i... Read More about Allelic shift in cis-elements of the transcription factor RAP2.12 underlies adaptation associated with humidity in Arabidopsis thaliana.

Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway (2022)
Journal Article

Mitochondrial retrograde signaling is an important component of intracellular stress signaling in eukaryotes. UNCOUPLING PROTEIN (UCP)1 is an abundant plant inner-mitochondrial membrane protein with multiple functions including uncoupled respiration... Read More about Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway.

A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions (2022)
Journal Article

The N-degron pathway is a branch of the ubiquitin-proteasome system where amino-terminal residues serve as degradation signals. In a synthetic biology approach, we expressed ubiquitin ligase PRT6 and ubiquitin conjugating enzyme 2 (AtUBC2) from Arabi... Read More about A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions.

Comparative Biology of Oxygen Sensing in Plants and Animals (2020)
Journal Article

© 2020 Elsevier Inc. Aerobic respiration is essential to almost all eukaryotes and sensing oxygen is a key determinant of survival. Analogous but mechanistically different oxygen-sensing pathways were adopted in plants and metazoan animals, and inclu... Read More about Comparative Biology of Oxygen Sensing in Plants and Animals.

The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development (2020)
Journal Article

© 2020 The Authors. New Phytologist © 2020 New Phytologist Trust VERNALIZATION2 (VRN2), an angiosperm-specific subunit of the polycomb repressive complex 2 (PRC2), is an oxygen (O2)-regulated target of the PCO branch of the PRT6 N-degron pathway of u... Read More about The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.

The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response (2019)
Journal Article

N-degron pathways of ubiquitin-mediated proteolysis (formerly known as the N-end rule pathway) control the stability of substrate proteins dependent on the amino-terminal (Nt) residue. Unlike yeast or mammalian N-recognin E3 ligases, which each recog... Read More about The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response.

The plant N?degron pathways of ubiquitin?mediated proteolysis (2019)
Journal Article

The amino?terminal residue of a protein (or amino?terminus of a peptide following protease cleavage) can be an important determinant of its stability, through the Ubiquitin?Proteasome?System associated N?degron pathways. Plants contain a unique combi... Read More about The plant N?degron pathways of ubiquitin?mediated proteolysis.

Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress (2019)
Journal Article

Timely perception of adverse environmental changes is critical for survival. Dynamic changes in gases are important cues for plants to sense environmental perturbations, such as submergence. In Arabidopsis thaliana, changes in oxygen and nitric oxide... Read More about Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress.

The Scope, Functions, and Dynamics of Posttranslational Protein Modifications (2019)
Journal Article

© 2019 by Annual Reviews. All rights reserved. Assessing posttranslational modification (PTM) patterns within protein molecules and reading their functional implications present grand challenges for plant biology. We combine four perspectives on PTMs... Read More about The Scope, Functions, and Dynamics of Posttranslational Protein Modifications.

Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION2 (2018)
Journal Article

The polycomb repressive complex 2 (PRC2) regulates epigenetic gene repression in eukaryotes. Mechanisms controlling its developmental specificity and signal-responsiveness are poorly understood. Here, we identify an oxygen-sensitive N-terminal (N-) d... Read More about Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION2.

A regulatory module controlling GA-mediated endosperm cell expansion is critical for seed germination in Arabidopsis (2018)
Journal Article

A key component of seed germination is the interplay of mechanical forces governing embryo growth and the surrounding restraining endosperm tissue. Endosperm cell separation is therefore thought to play a critical role in the control of this developm... Read More about A regulatory module controlling GA-mediated endosperm cell expansion is critical for seed germination in Arabidopsis.

Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment (2018)
Journal Article

The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant development, notably in the transition from dormant seed to photoautotrophic seedling. PROTEOLYSIS6 (PRT6), an N-recognin E3 ligase of the Arg/N-end... Read More about Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment.

Distinct branches of the N‐end rule pathway modulate the plant immune response (2018)
Journal Article

© 2018 The Authors. New Phytologist © 2018 New Phytologist Trust The N-end rule pathway is a highly conserved constituent of the ubiquitin proteasome system, yet little is known about its biological roles. Here we explored the role of the N-end rule... Read More about Distinct branches of the N‐end rule pathway modulate the plant immune response.

Sumoylation and phosphorylation: hidden and overt links (2018)
Journal Article

Post-translational modifications are essential mediators between stimuli from development or the environment and adaptive transcriptional patterns. Recent data allow a first glimpse at how two modifications, phosphorylation and sumoylation, act inter... Read More about Sumoylation and phosphorylation: hidden and overt links.

Finite indentation of highly curved elastic shells (2018)
Journal Article

Experimentally measuring the elastic properties of thin biological surfaces is non-trivial, particularly when they are curved. One technique that may be used is the indentation of a thin sheet of material by a rigid indenter, whilst measuring the app... Read More about Finite indentation of highly curved elastic shells.

N-term 2017: Proteostasis via the N-terminus (2017)
Journal Article

N-term 2017 was the first international meeting to bring together researchers from diverse disciplines with a shared interest in protein N-terminal modifications and the N-end rule pathway of ubiquitin-mediated proteolysis, providing a platform for i... Read More about N-term 2017: Proteostasis via the N-terminus.

N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway (2017)
Journal Article

The N-end rule pathway of targeted protein degradation is an important regulator of diverse processes in plants but detailed knowledge regarding its influence on the proteome is lacking. To investigate the impact of the Arg/N-end rule pathway on the... Read More about N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway.