Comparative Biology of Oxygen Sensing in Plants and Animals

Gibbs, Daniel J.; Holdsworth, Michael J.

Abstract

© 2020 Elsevier Inc. Aerobic respiration is essential to almost all eukaryotes and sensing oxygen is a key determinant of survival. Analogous but mechanistically different oxygen-sensing pathways were adopted in plants and metazoan animals, and include ubiquitin-mediated degradation of transcription factors and direct sensing via non-heme iron(Fe2+)-dependent-dioxygenases. Key roles for oxygen sensing have been identified in both groups, with downstream signalling focussed on regulating gene transcription and chromatin modification to control development and stress responses. Components of sensing systems are promising targets for human therapeutic intervention and developing stress-resilient crops. Here, we review current knowledge about the origins, commonalities and differences between oxygen sensing in plants and animals. Holdsworth and Gibbs review the comparative evolution and functions of oxygen-sensing in plants and animals, pathways that are analogous but mechanistically distinct, with essential roles in regulating gene expression and physiology.

• Journal Article Type: Review
• Acceptance Date: Mar 10, 2020
• Online Publication Date: Apr 20, 2020
• Publication Date: Apr 20, 2020
• Deposit Date: Mar 11, 2020
• Publicly Available Date: Apr 21, 2021
• Journal: Current Biology
• Print ISSN: 0960-9822
• Electronic ISSN: 1879-0445
• Publisher: Elsevier (Cell Press)
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 8
• Pages: R362-R369
• DOI: https://doi.org/10.1016/j.cub.2020.03.021
• Keywords: General Biochemistry, Genetics and Molecular Biology; General Agricultural and Biological Sciences
• Public URL: https://nottingham-repository.worktribe.com/output/4126924
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0960982220303596