All Outputs (75)

Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice (2022)
Journal Article

Background: Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of... Read More about Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice.

British Society of Gastroenterology guidelines on the management of functional dyspepsia (2022)
Journal Article

Functional dyspepsia (FD) is a common disorder of gut-brain interaction, affecting approximately 7% of individuals in the community, with most patients managed in primary care. The last British Society of Gastroenterology (BSG) guideline for the mana... Read More about British Society of Gastroenterology guidelines on the management of functional dyspepsia.

Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility (2022)
Journal Article

Irritable bowel syndrome with diarrhoea (IBS-D) and functional diarrhoea (FDr) are the two major functional bowel disorders characterized by diarrhoea. In spite of their high prevalence, IBS-D and FDr are associated with major uncertainties, especial... Read More about Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility.

Review article: rethinking the “ladder” approach to reflux-like symptom management in the era of PPI “resistance”: a multidisciplinary perspective (2022)
Journal Article

Background: Despite widespread adoption of potent acid suppression treatment with proton pump inhibitors (PPI) for reflux-like symptoms, persistent symptoms are commonly reported in primary care and community studies. Aims: This multidisciplinary rev... Read More about Review article: rethinking the “ladder” approach to reflux-like symptom management in the era of PPI “resistance”: a multidisciplinary perspective.

Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research (2022)
Journal Article

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Un... Read More about Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research.

The tapestry of reflux syndromes: translating new insight into clinical practice (2021)
Journal Article

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia (2021)
Journal Article

Background Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and p... Read More about United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia.

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on Functional Dyspepsia (2021)
Journal Article

Background Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and... Read More about United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on Functional Dyspepsia.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021)
Journal Article

Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication of the last British Society of Gastroenterology guideline in 2007, substantial advances... Read More about British Society of Gastroenterology guidelines on the management of irritable bowel syndrome.

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis (2021)
Journal Article

Background: Gastroparesis is a condition characterized by epigastric symptoms and delayed gastric emptying (GE) rate in the absence of any mechanical obstruction. The condition is challenging in clinical practice by the lack of guidance concerning... Read More about United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.

The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis (2021)
Journal Article

Background Clinical trials in irritable bowel syndrome are associated with high placebo response rates. We aimed to identify the magnitude of the placebo response and the contributing factors to this occurrence. Methods We did a systematic revie... Read More about The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis.

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review (2021)
Journal Article

The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populat... Read More about Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review.

Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation (2021)
Journal Article

Background: Bisacodyl is a member of the diphenylmethane family and is considered to be a stimulant laxative. It has a dual prokinetic and secretory action and needs to be converted into the active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (... Read More about Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment (2021)
Journal Article

Background: Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment.

High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications (2020)
Journal Article

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications.

High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications (2020)
Journal Article

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation (2020)
Journal Article

Chronic constipation is a prevalent disorder that affects patients’ quality of life and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treat... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation.

In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal (2020)
Journal Article

Food-drug interaction is an infrequently considered aspect in clinical practice. Usually, drugs are taken together with meals and what follows may adversely affect pharmacokinetic and pharmacodynamic properties, and hence, the therapeutic effects. In... Read More about In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal.

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants (2020)
Journal Article

Objective The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo dat... Read More about Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.

Irritable Bowel Syndrome (2020)
Journal Article

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose symptoms include abdominal pain associated with a change in stool form or frequency. The condition affects between 5% and 10% of otherwise healthy individuals in the commu... Read More about Irritable Bowel Syndrome.