High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications

Corsetti, Maura; Thys, Alexander; Harris, Alexander; Pagliaro, Giuseppe; Deloose, Eveline; Demedts, Ingrid; Tack, Jan

Abstract

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to directly stimulate the colonic motility in humans in vivo. As no previous study has done this, the aim of the study was to investigate the effect of PEG, bysacodyl and prucalopride as compared to placebo on colonic motility assessed by means of the high-resolution manometry (HRM) in healthy subjects.
Methods: 10 healthy subjects have been enrolled in an acute, open-label, randomized, reader-blinded, cross-over study and requested to undergo a colonoscopy-assisted HRM measuring their colonic motility before and after administration of 13.8 g (two doses) PEG, 10 mg bisacodyl, 2 mg prucalopride and placebo.
Results: in the human prepared colon, oral administration of PEG significantly increases the number of low amplitude long distance propagating contractions (P= 0.007 vs placebo) while bisacodyl significantly increases the number of high amplitude propagating contractions (HAPCs) (all P

• Journal Article Type: Article
• Acceptance Date: Nov 2, 2020
• Online Publication Date: Dec 10, 2020
• Publication Date: 2021-05
• Deposit Date: Jan 19, 2021
• Publicly Available Date: Dec 11, 2021
• Journal: Neurogastroenterology & Motility
• Print ISSN: 1350-1925
• Electronic ISSN: 1365-2982
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: 5
• Article Number: e14040
• DOI: https://doi.org/10.1111/nmo.14040
• Keywords: bisacodyl, colon motility, high-resolution manometry, PEG prucalopride
• Public URL: https://nottingham-repository.worktribe.com/output/5020633
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.14040
• Additional Information: Received: 2020-07-09; Accepted: 2020-11-02; Published: 2020-12-10