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Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice

Corsetti, Maura; Forestier, Sylvie; Jiménez, Marcel

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Authors

MAURA CORSETTI Maura.Corsetti@nottingham.ac.uk
Clinical Associate Professor

Sylvie Forestier

Marcel Jiménez



Abstract

Background: Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of HBB in vitro and in vivo in both animal and human studies. However, since then, novel publications have appeared within the literature and also our knowledge of what represents normal motility in humans has evolved. Purpose: This review is the result of the collaboration between a basic scientist and clinicians with the aim of providing an updated overview of the mechanisms of action of HBB and its clinical efficacy to guide not only use in clinical practice, but also future research.

Citation

Corsetti, M., Forestier, S., & Jiménez, M. (2023). Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice. Neurogastroenterology and Motility, 35(4), Article e14451. https://doi.org/10.1111/nmo.14451

Journal Article Type Article
Acceptance Date Aug 1, 2022
Online Publication Date Aug 16, 2022
Publication Date 2023-04
Deposit Date Aug 2, 2022
Publicly Available Date Aug 17, 2023
Journal Neurogastroenterology and Motility
Print ISSN 1350-1925
Electronic ISSN 1365-2982
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 35
Issue 4
Article Number e14451
DOI https://doi.org/10.1111/nmo.14451
Keywords Gastroenterology; Endocrine and Autonomic Systems; Physiology
Public URL https://nottingham-repository.worktribe.com/output/9581310
Publisher URL https://onlinelibrary.wiley.com/doi/10.1111/nmo.14451

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