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Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research


Stefan Senekowitsch

Philipp Schick

Bertil Abrahamsson

Patrick Augustijns



Christophe Matthys

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Professor of Gastrointestinal Imaging

Xavier Pepin

Alan Perkins


Sarah Sulaiman

Werner Weitschies

Clive G. Wilson

Mirko Koziolek


Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Understanding Gastrointestinal Absorption-related Processes (UNGAP)” was initiated in 2017, with the aim to improve the current comprehension of intestinal drug absorption and foster future developments in this field. In this regard, in vivo techniques used for the characterization of human GI physiology and the intraluminal behavior of orally administered dosage forms in the GI tract are fundamental to gaining deeper mechanistic understanding of the interplay between human GI physiology and drug product performance. In this review, the potential applications, advantages, and limitations of the most important in vivo techniques relevant to oral biopharmaceutics are presented from the perspectives of different research fields.


Senekowitsch, S., Schick, P., Abrahamsson, B., Augustijns, P., Gießmann, T., Lennernäs, H., …Koziolek, M. (2022). Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research. Pharmaceutics, 14(4), Article 801.

Journal Article Type Review
Acceptance Date Mar 27, 2022
Online Publication Date Apr 6, 2022
Publication Date Apr 6, 2022
Deposit Date Apr 6, 2022
Publicly Available Date Apr 11, 2022
Journal Pharmaceutics
Electronic ISSN 1999-4923
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 14
Issue 4
Article Number 801
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