All Outputs (101)

Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution (2015)
Journal Article

Magnetic resonance imaging (MRI) is a well established technique that has revolutionized diagnostic radiology. Until recently, the impact that MRI has had in the assessment of gastrointestinal motor function and bowel fluid distribution in health and... Read More about Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution.

Effect of bread gluten content on gastrointestinal function: a crossover MRI study on healthy humans (2015)
Journal Article

Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults (2015)
Journal Article

Background: Intragastric creaming and droplet size of fat emulsions may affect intragastric behavior and gastrointestinal and satiety responses. Objectives: We tested the hypotheses that gastrointestinal physiologic responses and satiety will be i... Read More about Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults.

A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors (2015)
Journal Article

Liver biopsy is the standard test for the assessment of fibrosis in liver tissue of patients with chronic liver disease. Recent studies have used a non‐invasive measure of T1 relaxation time to estimate the degree of fibrosis in a single slice of the... Read More about A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors.

Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteers: a 31P MRS study (2015)
Journal Article

Background: Impaired homeostasis of hepatic ATP has been associated with NAFLD. An intravenous fructose infusion has been shown to be an effective challenge to monitor the depletion and subsequent recovery of hepatic ATP reserves using 31P MRS. Aims... Read More about Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteers: a 31P MRS study.

Effect of experimental stress on the small bowel and colon in healthy humans (2015)
Journal Article

Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: a randomized, balanced, crossover trial (2015)
Journal Article

Measurement of gastric meal and secretion volumes using magnetic resonance imaging (2015)
Journal Article

MRI can assess multiple gastric functions without ionizing radiation. However, time consuming image acquisition and analysis of gastric volume data, plus confounding of gastric emptying measurements by gastric secretions mixed with the test meal have... Read More about Measurement of gastric meal and secretion volumes using magnetic resonance imaging.

Effects of bowel cleansing on the intestinal microbiota (2014)
Journal Article

Objective: An adequate bowel cleansing is essential for a successful colonoscopy. Although purgative consumption is safe for the patient, there is little consensus on how the intestinal microbiota is affected by the procedure, especially regarding th... Read More about Effects of bowel cleansing on the intestinal microbiota.

Additive effects of gastric volumes and macronutrient composition on the sensation of postprandial fullness in humans (2014)
Journal Article

Background/Objectives: Intake of food or fluid distends the stomach and triggers mechanoreceptors and vagal afferents. Wall stretch and tension produces a feeling of fullness. Duodenal infusion studies assessing gastric sensitivity by barostat have s... Read More about Additive effects of gastric volumes and macronutrient composition on the sensation of postprandial fullness in humans.

Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state (2014)
Journal Article

Previous imaging studies offered a snapshot of water distribution in fasted humans and showed that water in the small intestine is distributed in small pockets. This study aimed to quantify the volume and number of water pockets in the upper gut of f... Read More about Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state.

Magnetic resonance spectroscopy measurements of intragastric fat fraction of oil emulsions in humans (2014)
Journal Article

Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of splitvssingle dose (2014)
Journal Article

A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo 13C magnetic resonance study (2014)
Journal Article

Previous studies have reported a meal-induced rise in hepatic glycogen stores from baseline levels following a fast and it is generally assumed that glycogen levels rise steadily following meals throughout the day. However, measurements are normally... Read More about A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo 13C magnetic resonance study.

Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI (2014)
Journal Article

OBJECTIVES:The objective of this study was to investigate whether ingestion of fructose and fructans (such as inulin) can exacerbate irritable bowel syndrome (IBS) symptoms. The aim was to better understand the origin of these symptoms by magnetic re... Read More about Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI.

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea (2013)
Journal Article

Background: Irritable bowel syndrome with diarrhoea (IBS-D) is particularly debilitating due to urgency and episodic incontinence. Some 5-hydroxytryptamine 3 (5-HT3) receptor antagonists (5-HT3RAs) have proven effective but have serious side effects.... Read More about A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea.

Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects (2013)
Journal Article

Background: Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation. The aim of this study was to compare novel magnetic resonance imaging (MRI) tests for mea... Read More about Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects.

Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI (2013)
Journal Article

Background Previous assessments of colon morphology have relied on tests which were either invasive or used ionizing radiation. We aimed to measure regional volumes of the undisturbed colon in healthy volunteers (HV) and patients with diarrhea-predo... Read More about Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI.

Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit (2013)
Journal Article

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights (2013)
Journal Article

BACKGROUND/OBJECTIVES: Postprandial bloating is a common symptom in patients with functional gastrointestinal (GI) diseases. Whole meal bread (WMB) often aggravates such symptoms though the mechanisms are unclear. We used magnetic resonance imaging (... Read More about Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights.