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Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI

Murray, Kathryn; Wilkinson-Smith, Victoria; Hoad, Caroline; Costigan, Carolyn; Cox, Eleanor; Lam, Ching; Marciani, Luca; Gowland, Penny A.; Spiller, Robin C.

Authors

Kathryn Murray

Victoria Wilkinson-Smith

Carolyn Costigan

ELEANOR COX ELEANOR.COX@NOTTINGHAM.AC.UK
Senior Research Fellow

Ching Lam

LUCA MARCIANI LUCA.MARCIANI@NOTTINGHAM.AC.UK
Professor of Gastrointestinal Imaging

Penny A. Gowland

Robin C. Spiller



Abstract

OBJECTIVES:The objective of this study was to investigate whether ingestion of fructose and fructans (such as inulin) can exacerbate irritable bowel syndrome (IBS) symptoms. The aim was to better understand the origin of these symptoms by magnetic resonance imaging (MRI) of the gut. METHODS: A total of 16 healthy volunteers participated in a four-way, randomized, single-blind, crossover study in which they consumed 500 ml of water containing 40 g of either glucose, fructose, inulin, or a 1:1 mixture of 40 g glucose and 40 g fructose. MRI scans were performed hourly for 5 h, assessing the volume of gastric contents, small bowel water content (SBWC), and colonic gas. Breath hydrogen (H 2) was measured and symptoms recorded after each scan.RESULTS:Data are reported as mean (s.d.) (95% CI) when normally distributed and median (range) when not. Fructose increased area under the curve (AUC) from 0-5 h of SBWC to 71 (23) l/min, significantly greater than for glucose at 36 (11-132) l/min (P

Citation

Murray, K., Wilkinson-Smith, V., Hoad, C., Costigan, C., Cox, E., Lam, C., …Spiller, R. C. (2014). Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI. American Journal of Gastroenterology, 109(1), 110-119. https://doi.org/10.1038/ajg.2013.386

Journal Article Type Article
Acceptance Date Oct 4, 2013
Publication Date 2014-01
Deposit Date Mar 28, 2014
Publicly Available Date Mar 28, 2014
Journal American Journal of Gastroenterology
Print ISSN 0002-9270
Electronic ISSN 1572-0241
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 109
Issue 1
Pages 110-119
DOI https://doi.org/10.1038/ajg.2013.386
Keywords Hepatology; Gastroenterology
Public URL http://eprints.nottingham.ac.uk/id/eprint/2748
Publisher URL http://www.nature.com/ajg/journal/v109/n1/full/ajg2013386a.html
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-sa/4.0/





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