Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI

Murray, Kathryn; Wilkinson-Smith, Victoria; Hoad, Caroline; Costigan, Carolyn; Cox, Eleanor; Lam, Ching; Marciani, Luca; Gowland, Penny A.; Spiller, Robin C.

Abstract

OBJECTIVES:The objective of this study was to investigate whether ingestion of fructose and fructans (such as inulin) can exacerbate irritable bowel syndrome (IBS) symptoms. The aim was to better understand the origin of these symptoms by magnetic resonance imaging (MRI) of the gut. METHODS: A total of 16 healthy volunteers participated in a four-way, randomized, single-blind, crossover study in which they consumed 500 ml of water containing 40 g of either glucose, fructose, inulin, or a 1:1 mixture of 40 g glucose and 40 g fructose. MRI scans were performed hourly for 5 h, assessing the volume of gastric contents, small bowel water content (SBWC), and colonic gas. Breath hydrogen (H 2) was measured and symptoms recorded after each scan.RESULTS:Data are reported as mean (s.d.) (95% CI) when normally distributed and median (range) when not. Fructose increased area under the curve (AUC) from 0-5 h of SBWC to 71 (23) l/min, significantly greater than for glucose at 36 (11-132) l/min (P

Citation

Murray, K., Wilkinson-Smith, V., Hoad, C., Costigan, C., Cox, E., Lam, C., Marciani, L., Gowland, P. A., & Spiller, R. C. (2014). Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI. American Journal of Gastroenterology, 109(1), 110-119. https://doi.org/10.1038/ajg.2013.386

• Journal Article Type: Article
• Acceptance Date: Oct 4, 2013
• Publication Date: 2014-01
• Deposit Date: Mar 28, 2014
• Publicly Available Date: Mar 28, 2014
• Journal: American Journal of Gastroenterology
• Print ISSN: 0002-9270
• Electronic ISSN: 1572-0241
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 109
• Issue: 1
• Pages: 110-119
• DOI: https://doi.org/10.1038/ajg.2013.386
• Keywords: Hepatology; Gastroenterology
• Public URL: https://nottingham-repository.worktribe.com/output/718624
• Publisher URL: http://www.nature.com/ajg/journal/v109/n1/full/ajg2013386a.html