All Outputs (14)

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies (2021)
Journal Article
Scaife, P. J., Simpson, A., Kurlak, L. O., Briggs, L. V., Gardner, D. S., Pipkin, F. B., …Mistry, H. D. (2021). Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies. International Journal of Molecular Sciences, 22(14), Article 7295. https://doi.org/10.3390/ijms22147295

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu... Read More about Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies.

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia (2020)
Journal Article
Stratikos, E., Warthan, M., Strauss, J. F., Kurlak, L. O., Seamon, K., Lee, E. D., & Mistry, H. D. (2020). The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia. Frontiers in Immunology, 11, Article 396. https://doi.org/10.3389/fimmu.2020.00396

Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta. They are involved in processes regulating blood pressure, angioge... Read More about The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia.

A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy (2020)
Journal Article
Dahabiyeh, L. A., Tooth, D., Kurlak, L. O., Mistry, H. D., Pipkin, F. B., & Barrett, D. A. (2020). A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy. Scientific Reports, 10(1), Article 1956. https://doi.org/10.1038/s41598-020-58930-7

© 2020, The Author(s). The oxidation status of angiotensinogen (AGT) may have a critical role in pre-eclampsia. We used a validated, quantitative, mass spectrometry-based method to measure the oxidized and total AGT levels in plasma of pre-eclamptic... Read More about A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy.

Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia (2019)
Journal Article
Kurlak, L. O., Broughton Pipkin, F., Mohaupt, M. G., & Mistry, H. D. (2019). Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia. Clinical Kidney Journal, 12(6), 847-854. https://doi.org/10.1093/ckj/sfz025

Background: Women with chronic kidney disease (CKD) are at increased risk of superimposed preeclampsia (SPE). Accurate identification of SPE is challenging. We hypothesised that specific components of the renin-angiotensin-aldosterone-system (RAAS) w... Read More about Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia.

Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension (2018)
Journal Article
Escouto, D. C., Green, A., Kurlak, L., Walker, K., Loughna, P., Chappell, L., Broughton Pipkin, F., & Bramham, K. (2018). Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension. Pregnancy Hypertension, 13, 218-224. https://doi.org/10.1016/j.preghy.2018.06.019

Objectives: Postpartum stratification of cardiovascular risk for women with pregnancies complicated by pre-eclampsia is challenging. Our aim was to identify potential clinical and biomarker predictors of future cardiovascular risk at six weeks postpa... Read More about Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension.

Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult (2016)
Journal Article
Kurlak, L., Mistry, H. D., Cindrova-Davies, T., Burton, G., & Broughton Pipkin, F. (2016). Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult. Journal of Physiology, 594(5), 1327-1340. https://doi.org/10.1113/JP271045

A functioning placental renin–angiotensin system (RAS) appears necessary for uncomplicated pregnancy and is present during placentation, which occurs under low oxygen tensions. Placental RAS is increased in pre-eclampsia (PE), characterised by placen... Read More about Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult.

Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year (2015)
Journal Article
Broughton Pipkin, F., Mistry, H. D., Roy, C., Dick, B., Waugh, J., Chikhi, R., Kurlak, L., & Mohaupt, M. (2015). Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year. Endocrine Connections, 4(4), https://doi.org/10.1530/EC-15-0084

Pre-eclampsia leads to disturbed fetal organ development, including metabolic syndrome, attributed to altered pituitary-adrenal feedback loop. We measured cortisol metabolites in infants born from pre-eclamptic and normotensive women and hypothesised... Read More about Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year.

Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system (2015)
Journal Article
Kurlak, L., Williams, P. J., Bulmer, J. N., Broughton Pipkin, F., & Mistry, H. D. (2015). Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.011

Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiog... Read More about Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system.

Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia (2014)
Journal Article
Mistry, H. D., Gill, C., Kurlak, L., Seed, P. T., Hestketh, J., Meplan, C., Schomburg, L., Chappell, L. C., Morgan, L., & Poston, L. (2015). Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia. Free Radical Biology and Medicine, 78, https://doi.org/10.1016/j.freeradbiomed.2014.10.580

Aims: Pre-eclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Deficiencies of specific micronutrient antioxidant activities associated with copper, selenium, zinc... Read More about Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia.

Expression of voltage-dependent potassium channels in first trimester human placentae (2014)
Journal Article
Mistry, H. D., Kurlak, L., Whitley, G. S., Cartwright, J. E., Broughton Pipkin, F., & Tribe, R. M. (2014). Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35(5), https://doi.org/10.1016/j.placenta.2014.02.008

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCN... Read More about Expression of voltage-dependent potassium channels in first trimester human placentae.

Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype (2013)
Journal Article
Hentchke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Kurlak, L., Williams, P. J., & Mistry, H. D. (2013). Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype. Journal of Lipid Research, 54, https://doi.org/10.1194/jlr.M036699

Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-... Read More about Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype.

Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy (2013)
Journal Article
Kurlak, L., Mistry, H., Kaptein, E., Visser, T., & Broughton Pipkin, F. (2013). Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy. Placenta, 34(5), https://doi.org/10.1016/j.placenta.2013.02.009

Pre-eclampsia is associated with lower serum selenium concentrations and glutathione peroxidase expression/activity; total thyroid hormones are also lower.
Objectives, study design and main outcome measures: We hypothesised that the placental seleno... Read More about Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy.

Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia (2011)
Journal Article
Mistry, H. D., McCallum, L. A., Kurlak, L. O., Greenwood, I. A., Broughton Pipkin, F., & Tribe, R. M. (2011). Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia. Hypertension, 58, https://doi.org/10.1161/HYPERTENSIONAHA.111.173740

Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. KV7 (voltage-dependant potassium channels encoded by KCNQ1-5 genes) have been detected in several types of blood vessels where they promote vascu... Read More about Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia.

Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung (2007)
Journal Article
Yakubu, D., Mostyn, A., Hyatt, M., Kurlak, L., Budge, H., Stephenson, T., & Symonds, M. E. (2007). Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung. Reproduction, 134, https://doi.org/10.1530/REP-07-0155

This study investigated the developmental and nutritional programming of two important mitochondrial proteins, namely voltage dependent anion channel (VDAC) and cytochrome c in the sheep kidney, liver and lung. The effect of maternal nutrient restric... Read More about Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung.