All Outputs (95)

An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development (2021)
Journal Article

Background & Aims: Development of a prophylactic hepatitis C virus (HCV) vaccine will require accurate and reproducible measurement of neutralizing breadth of vaccine-induced antibodies. Currently available HCV panels may not adequately represent the... Read More about An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development.

Impacts of the COVID-19 pandemic and self-isolation on students and staff in higher education: A qualitative study (2021)
Journal Article

This qualitative study explored the impact of COVID-19 self-isolation and social restriction measures on university students, through the perspectives of both students and the staff supporting them. The study comprised 11 focus groups (students) and... Read More about Impacts of the COVID-19 pandemic and self-isolation on students and staff in higher education: A qualitative study.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

Prospective examination of mental health in university students during the COVID-19 pandemic (2021)
Working Paper

Background The impact of changing social restrictions on the mental health of students during the COVID-19 pandemic warrants exploration. Aims To prospectively examine changes to university students’ mental health during the pandemic. Methods S... Read More about Prospective examination of mental health in university students during the COVID-19 pandemic.

Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study (2021)
Journal Article

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation, during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups condu... Read More about Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study.

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2021)
Presentation / Conference

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2021)
Presentation / Conference

Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study (2021)
Working Paper

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups conduc... Read More about Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study.

Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort (2020)
Working Paper

Objective: This study examined the COVID-19 risk perceptions and mental health of university students on returning to campus in the midst of the COVID-19 pandemic. Methods: An online survey was completed during the first four weeks of the academic... Read More about Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort.

Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (2020)
Journal Article

The emergence of SARS-CoV-2 highlights the global need for platform technologies to enable the rapid development of diagnostics, vaccines, treatments, and personal protective equipment (PPE). However, many current technologies require the detailed me... Read More about Polymer microarrays rapidly identify competitive adsorbents of virus-like particles.

Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs) (2020)
Journal Article

The emergence of SARS-CoV-2 highlights the global need for platform technologies to enable rapid development of diagnostics, vaccines, treatments, and personal protective equipment (PPE). However, many current technologies require the detailed mechan... Read More about Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs).

All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2 (2020)
Journal Article

© 2020 Elsevier Inc. The world faces a severe and acute public health emergency due to the ongoing coronavirus disease 2019 (COVID-19) global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Healthcare workers are... Read More about All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2.

Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV (2020)
Journal Article

Despite available treatments, a prophylactic HCV vaccine is needed to achieve elimination targets. HCV vaccine development has faltered largely because the extreme diversity of the virus limits the protective breadth of vaccine elicited antibodies. I... Read More about Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV.

A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice (2020)
Journal Article

© 2020 Elsevier Ltd Vaccine development for antigenically variable pathogens has faltered because extreme genetic diversity precludes induction of broadly neutralizing antibodies (nAB) with classical vaccines. Here, using the most variable epitope of... Read More about A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice.

Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization (2020)
Journal Article

Copyright © 2020 American Society for Microbiology. An effective vaccine for hepatitis C virus (HCV) is a major unmet need, and it requires an antigen that elicits immune responses to key conserved epitopes. Based on structures of antibodies targetin... Read More about Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.

A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C (2020)
Journal Article

Rabies, caused by RNA viruses in the Genus Lyssavirus, is the most fatal of all infectious diseases. This neglected zoonosis remains a major public health problem in developing countries, causing the death of an estimated 25,000-159,000 people each y... Read More about A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C.

Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species (2020)
Journal Article

©2020 by the authors. Licensee MDPI, Basel, Switzerland. Orthohantaviruses are globally distributed viruses, associated with rodents and other small mammals. However, data on the circulation of orthohantaviruses within the UK, particularly the UK-end... Read More about Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species.

Hepatitis C virus vaccine: Challenges and prospects (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The hepatitis C virus (HCV) causes both acute and chronic infection and continues to be a global problem despite advances in antiviral therapeutics. Current treatments fail to prevent reinfect... Read More about Hepatitis C virus vaccine: Challenges and prospects.

Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits (2019)
Journal Article

The advent of unbiased metagenomic virus discovery has revolutionized studies of virus biodiversity and evolution. Despite this, our knowledge of the virosphere, including in mammalian species, remains limited. We used unbiased metagenomic sequencing... Read More about Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits.

Identification of infectious agents in high-throughput sequencing data sets is easily achievable using free, cloud-based bioinformatics platforms (2019)
Journal Article