A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice

Mosa, Alexander I.; Urbanowicz, Richard A.; AbouHaidar, Mounir G.; Tavis, John E.; Ball, Jonathan K.; Feld, Jordan J.

Abstract

© 2020 Elsevier Ltd Vaccine development for antigenically variable pathogens has faltered because extreme genetic diversity precludes induction of broadly neutralizing antibodies (nAB) with classical vaccines. Here, using the most variable epitope of any known human pathogen (HVR1 of HCV), we describe a novel approach capable of eliciting broadly neutralizing antibodies targeting highly variable epitopes. Our proof-of-concept vaccine elicited pan-genotypic nAB against HCV variants differing from the immunogen sequences by more than 70% at the amino acid level. These findings suggest broadly nAB to highly variable pathogens can be elicited by vaccines designed to target physicochemically conserved residues within hypervariable epitopes.

Citation

Mosa, A. I., Urbanowicz, R. A., AbouHaidar, M. G., Tavis, J. E., Ball, J. K., & Feld, J. J. (2020). A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice. Vaccine, 38(44), 6864-6867. https://doi.org/10.1016/j.vaccine.2020.08.066

• Journal Article Type: Article
• Acceptance Date: Aug 25, 2020
• Online Publication Date: Sep 6, 2020
• Publication Date: Oct 14, 2020
• Deposit Date: Jan 5, 2021
• Publicly Available Date: Sep 7, 2021
• Journal: Vaccine
• Print ISSN: 0264-410X
• Electronic ISSN: 1873-2518
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 38
• Issue: 44
• Pages: 6864-6867
• DOI: https://doi.org/10.1016/j.vaccine.2020.08.066
• Keywords: Infectious Diseases; Public Health, Environmental and Occupational Health; General Veterinary; General Immunology and Microbiology; Molecular Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/4913610
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0264410X2031118X?via%3Dihub