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Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits

Tsoleridis, Theocharis; Chappell, Joseph G.; Monchatre-Leroy, Elodie; Umhang, Gérald; Shi, Mang; Bennett, Malcolm; Tarlinton, Rachael E.; McClure, C. Patrick; Holmes, Edward C.; Ball, Jonathan K.

Authors

Theocharis Tsoleridis

Elodie Monchatre-Leroy

Gérald Umhang

Mang Shi

Malcolm Bennett

Rachael E. Tarlinton

C. Patrick McClure

Edward C. Holmes

Jonathan K. Ball



Abstract

The advent of unbiased metagenomic virus discovery has revolutionized studies of virus biodiversity and evolution. Despite this, our knowledge of the virosphere, including in mammalian species, remains limited. We used unbiased metagenomic sequencing to identify RNA viruses in European field voles and rabbits. Accordingly, we identified a number of novel RNA viruses including astrovirus, rotavirus A, picorna-like virus and a morbilli-like paramyxovirus. In addition, we identified a sobemovirus and a novel luteovirus that likely originated from the rabbit diet. These newly discovered viruses were often divergent from those previously described. The novel astrovirus was most closely related to a virus sampled from the rodent-eating European roller bird (Coracias garrulous). PCR screening revealed that the novel morbilli-like paramyxovirus in the UK field vole had a prevalence of approximately 4%, and shared common ancestry with other rodent morbilli-like viruses sampled globally. Two novel rotavirus A sequences were detected in a UK field vole and a French rabbit, the latter with a prevalence of 5%. Finally, a highly divergent picorna-like virus found in the gut of the French rabbit virus was only ~35% similar to an arilivirus at the amino acid level, suggesting the presence of a novel viral genus within the Picornaviridae.

Journal Article Type Article
Publication Date Dec 31, 2019
Journal Viruses
Electronic ISSN 1999-4915
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 12
Issue 1
Article Number 47
APA6 Citation Tsoleridis, T., Chappell, J. G., Monchatre-Leroy, E., Umhang, G., Shi, M., Bennett, M., …Ball, J. K. (2019). Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits. Viruses, 12(1), https://doi.org/10.3390/v12010047
DOI https://doi.org/10.3390/v12010047
Keywords Virology; Infectious Diseases
Publisher URL https://www.mdpi.com/1999-4915/12/1/47

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