All Outputs (64)

Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry (2016)
Journal Article

Oral delivery of pharmaceuticals requires that they retain their physical and chemical attributes during transit within the gastrointestinal (GI) tract, for the manifestation of desired therapeutic profiles. Solid lipid nanoparticles (SLNs) are used... Read More about Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry.

Disruption of diphenylalanine assembly by a Boc-modified variant (2016)
Journal Article

Peptide-based biomaterials are key to the future of diagnostics and therapy, promoting applications such as tissue scaffolds and drug delivery vehicles. To realise the full potential of the peptide systems, control and optimisation of material proper... Read More about Disruption of diphenylalanine assembly by a Boc-modified variant.

Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon (2016)
Journal Article

In the present study, we report the properties of a mucoadhesive chitosan-pectinate nanoparticulate formulation able to retain its integrity in the milieu of the upper gastrointestinal tract and subsequently, mucoadhere and release curcumin in colon... Read More about Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon.

Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly (2016)
Journal Article

Molecular self-assembly of peptides into ordered nanotubes is highly important for various technological applications. Very short peptide building blocks, as short as dipeptides, can form assemblies with unique mechanical, optical, piezoelectric, and... Read More about Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly.

Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials (2016)
Journal Article

The structure of a material, in particular the extremes of crystalline and amorphous forms, significantly impacts material performance in numerous sectors such as semiconductors, energy storage, and pharmaceutical products, which are investigated in... Read More about Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials.

The effect of protein concentration on the viscosity of a recombinant albumin solution formulation (2016)
Journal Article

The effect of protein concentration on solution viscosity in a commercially available biopharmaceutical formulation of recombinant albumin (rAlbumin) was studied. The level of protein aggregation with concentration and its impact on solution viscosit... Read More about The effect of protein concentration on the viscosity of a recombinant albumin solution formulation.

Study of the effect of dipole interactions on hyperthermia heating the cluster composed of superparamagnetic nanoparticles (2015)
Journal Article

3D printing of tablets containing multiple drugs with defined release profiles (2015)
Journal Article

3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles (2015)
Journal Article

We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypil... Read More about 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.

Facile approach to generating polymeric nanoarrays containing populations of nanoparticles (2015)
Journal Article

The production of nanoarrays containing a population of entrapped, heterogeneous nanoparticles is reported. The nanoarray consists of a nanoporous film with pores of diameter 60-180 nm, formed from the phase separation of two immiscible polymers: pol... Read More about Facile approach to generating polymeric nanoarrays containing populations of nanoparticles.

Long-term amorphous drug stability predictions using easily calculated, predicted, and measured parameters (2015)
Journal Article

Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates (2015)
Journal Article

We demonstrate in this work the deposition of a large biological molecule (fibronectin) on polymeric substrates in a high vacuum environment using an electrospray deposition system. Fibronectin was deposited and its distribution and structure investi... Read More about Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates.

The Influence of Spray-Drying Parameters on Phase Behavior, Drug Distribution, and In Vitro Release of Injectable Microspheres for Sustained Release (2015)
Journal Article

Analysis of leaf surfaces using scanning ion conductance microscopy (2015)
Journal Article

Leaf surfaces are highly complex functional systems with well defined chemistry and structure dictating the barrier and transport properties of the leaf cuticle. It is a significant imaging challenge to analyse the very thin and often complex wax-lik... Read More about Analysis of leaf surfaces using scanning ion conductance microscopy.

Characterisation of human saliva as a platform for oral dissolution medium development (2015)
Journal Article

Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develo... Read More about Characterisation of human saliva as a platform for oral dissolution medium development.

Study of NAP adsorption and assembly on the surface of HOPG (2014)
Journal Article

NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here... Read More about Study of NAP adsorption and assembly on the surface of HOPG.

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor (2014)
Journal Article

At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides a... Read More about In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor.

Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions (2014)
Journal Article

Purpose: Miscibility of the different compounds that make up a solid dispersion based formulation play a crucial role in the drug release profile and physical stability of the solid dispersion as it defines the phase behaviour of the dispersion. The... Read More about Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions.

Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide (2014)
Journal Article

A two-dimensional porous network formed from perylene tetracarboxylic diimide (PTCDI) and melamine may be deposited from solution on the surfaces of highly oriented pyrolytic graphite (HOPG), hexagonal boron nitride (hBN) and molybdenum disulphide (... Read More about Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide.

Desktop 3D printing of controlled release pharmaceutical bilayer tablets (2013)
Journal Article

Three dimensional (3D) printing was used as a novel medicine formulation technique for production of viable tablets capable of satisfying regulatory tests and matching the release of standard commercial tablets. Hydroxypropyl methylcellulose (HPMC 22... Read More about Desktop 3D printing of controlled release pharmaceutical bilayer tablets.