All Outputs (17)

A review of experimental models of focal cerebral ischemia focusing on the middle cerebral artery occlusion model (2021)
Journal Article

Cerebral ischemic stroke is a leading cause of death and disability, but current pharmacological therapies are limited in their utility and effectiveness. In vitro and in vivo models of ischemic stroke have been developed which allow us to further el... Read More about A review of experimental models of focal cerebral ischemia focusing on the middle cerebral artery occlusion model.

Longitudinal Multimodal fMRI to Investigate Neurovascular Changes in Spontaneously Hypertensive Rats (2020)
Journal Article

Hypertension is an important risk factor for age?related cognitive decline and neuronal pathologies. Studies have shown a correlation between hypertension, disruption in neurovascular coupling and cerebral autoregulation, and cognitive decline. Howev... Read More about Longitudinal Multimodal fMRI to Investigate Neurovascular Changes in Spontaneously Hypertensive Rats.

A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain (2020)
Journal Article

As the population ages, the incidence of age-related neurological diseases and cognitive decline increases. To further understand disease-related changes in brain function it is advantageous to examine brain activity changes in healthy aging rodent m... Read More about A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain.

Improved reperfusion following alternative surgical approach for experimental stroke in mice (2020)
Journal Article

Improved reperfusion following alternative surgical approach for experimental stroke in mice [version 3; peer review: 2 approved] (2020)
Journal Article

Improved reperfusion following alternative surgical approach for experimental stroke in mice (2020)
Journal Article

Background: Following ischemic stroke, recanalisation and restoration of blood flow to the affected area of the brain is critical and directly correlates with patient recovery. In vivo models of ischemic stroke show high variability in outcomes whic... Read More about Improved reperfusion following alternative surgical approach for experimental stroke in mice.

Sexual dimorphism following in vitro ischemia in the response to neurosteroids and mechanisms of injury (2020)
Journal Article

Imaging functional recovery following ischemic stroke: clinical and preclinical fMRI studies (2019)
Journal Article

Disability and effectiveness of physical therapy are highly variable following ischemic stroke due to different brain regions being affected. Functional magnetic resonance imaging (fMRI) studies of patients in the months and years following stroke ha... Read More about Imaging functional recovery following ischemic stroke: clinical and preclinical fMRI studies.

Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia (2018)
Journal Article

Experimental stroke in rodents, via middle cerebral artery occlusion (MCAO), can be associated with a negative impact on wellbeing and mortality. In hypertensive rodents, pre-stroke craniotomy increased survival and decreased body weight loss post-MC... Read More about Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia.

The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) (2017)
Journal Article

Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and ani... Read More about The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).

An alternative surgical approach reduces variability following filament induction of experimental stroke in mice (2017)
Journal Article

The Dichotomy of Memantine Treatment for Ischemic Stroke: Dose-Dependent Protective and Detrimental Effects (2014)
Journal Article

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions (2014)
Journal Article

Ischaemic strokes evoke blood–brain barrier (BBB) disruption and oedema formation through a series of mechanisms involving Rho-kinase activation. Using an animal model of human focal cerebral ischaemia, this study assessed and confirmed the therapeut... Read More about Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.

Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review (2009)
Journal Article

Background: Granulocyte-colony stimulating factor (G-CSF) shows promise as a treatment for stroke. This systematic review assesses G-CSF in experimental ischaemic stroke. Methods: Relevant studies were identified with searches of Medline, Embase and... Read More about Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review.

Estrogen and experimental ischemic stroke: a systematic review (2006)
Journal Article

Nitric oxide synthase inhibitors in experimental stroke and their effects on infarct size and cerebral blood flow: a systematic review (2005)
Journal Article

A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow (2005)
Journal Article

Background: Nitric oxide (NO) is a candidate treatment for acute ischaemic stroke, however published studies in experimental stroke have given conflicting results. Methods: We performed a systematic review of published controlled studies of L-arginin... Read More about A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow.