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A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow

Willmot, Mark; Gray, Laura J.; Gibson, Claire L.; Murphy, Sean; Bath, Philip M.W.

Authors

Mark Willmot

Laura J. Gray

Claire L. Gibson

Sean Murphy

Philip M.W. Bath



Abstract

Background: Nitric oxide (NO) is a candidate treatment for acute ischaemic stroke, however published studies in experimental stroke have given conflicting results. Methods: We performed a systematic review of published controlled studies of L-arginine (the precursor for NO) and NO donors in experimental stroke. Data were analysed using the Cochrane Collaboration Review Manager software. Standardised mean difference (SMD) and 95% confidence intervals (95% CI) were calculated. Results: Altogether, 25 studies (s) were identified. L-arginine and NO donors reduced total cerebral infarct volume in permanent (SMD -1.21, 95% CI -1.69 to -0.73, p

Journal Article Type Article
Publication Date Jan 1, 2005
Journal Nitric Oxide
Print ISSN 1089-8603
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 12
Issue 3
APA6 Citation Willmot, M., Gray, L. J., Gibson, C. L., Murphy, S., & Bath, P. M. (2005). A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow. Nitric Oxide: Biology and Chemistry, 12(3),
Keywords Nitric oxide donors
Stroke
Animal models
L-Arginine
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
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