All Outputs (17)

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2024)
Journal Article

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and seve... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review (2023)
Journal Article

Coronavirus disease 2019 (COVID-19) can lead to ongoing symptoms such as breathlessness, fatigue and muscle pain, which can have a substantial impact on an individual. Exercise-based rehabilitation programmes have proven beneficial in many long-term... Read More about Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review.

Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study (2023)
Journal Article

Pulmonary rehabilitation marches on: refining, optimising and delivering through the clinical statement (2023)
Journal Article

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Working Paper

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation (2023)
Journal Article

Household air pollution caused by inefficient cooking practices causes 4 million deaths a year worldwide. In Nepal, 86% of the rural population use solid fuels for cooking. Over 25% of premature deaths associated with air pollution are respiratory in... Read More about Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation.

Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis (2023)
Journal Article

Objective: Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19. Design: Multicentre prospective observational cohort study using questionnaire data at visit 1 (2–7 mont... Read More about Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis.

Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS) (2023)
Journal Article

Objective: To assess whether antidepressant prescriptions are associated with an increased risk of pneumonia and chronic obstructive pulmonary disease (COPD) exacerbation. Methods: A self-controlled case series was performed to investigate the rates... Read More about Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS).

Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID) (2023)
Working Paper

PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged. PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitali... Read More about Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID).

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study (2023)
Journal Article

Sleep disturbance is common following hospital admission both for COVID-19 and other causes. The clinical associations of this for recovery after hospital admission are poorly understood despite sleep disturbance contributing to morbidity in other sc... Read More about Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (2023)
Journal Article

Background: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods: This prospective cohort study recruited adults who had survived hospitalisation with clinically d... Read More about Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.

The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study (2022)
Working Paper

Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation (2022)
Journal Article

Purpose: People with COPD are at a higher risk of cognitive dysfunction than the general population. However, the additional impact of dementia amongst such patients is not well understood, particularly in those admitted with a COPD exacerbation. We... Read More about Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation.

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19 (2022)
Journal Article

Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts,... Read More about Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19.

Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis (2022)
Working Paper

Background Acute COVID-19 clinical symptoms have been clearly documented, but long-term functional and symptomatic recovery from COVID -19 is less well described. Methods A systematic review and meta-analysis were conducted to describe patient-rep... Read More about Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis.

Developing good practice by understanding how UK medical schools address low level concerns: a survey study (2021)
Journal Article

In the literature, a distinction is made between low-level concerns and what is regarded as fitness to practise concerns. The General Medical Council expects all UK medical schools to have a transparent process in place about how concerns about its m... Read More about Developing good practice by understanding how UK medical schools address low level concerns: a survey study.

Improving lung health in low-income and middle-income countries: from challenges to solutions (2021)
Journal Article

Low-income and middle-income countries (LMICs) bear a disproportionately high burden of the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including asthma, chronic obstructive pulmonary disease, bronchiectasis, and pos... Read More about Improving lung health in low-income and middle-income countries: from challenges to solutions.