Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Huang, Jeffrey; Shek, Naomi; Choy, Anna-Maria; Lang, Chim; Miller, Bruce; Tal-Singer, Ruth; Bolton, Charlotte; Thomson, Neil; Newby, David; Chalmers, James; Khan, Faisel; Brown, Matthew

Abstract

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

• Deposit Date: Feb 29, 2024
• Publicly Available Date: Mar 5, 2024
• Public URL: https://nottingham-repository.worktribe.com/output/27086594
• Publisher URL: https://www.researchsquare.com/article/rs-3379154/v1
• Additional Information: This is a preprint; it has not been peer reviewed by a journal.