Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Shek, Naomi; Choy, Anna-Maria; Lang, Chim C; Miller, Bruce E; Tal-Singer, Ruth; Bolton, Charlotte E; Thomson, Neil C; Chalmers, James D; Bown, Matt J; Newby, David E; Khan, Faisel; Huang, Jeffrey T J

Abstract

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

Citation

Shek, N., Choy, A., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., …Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), Article 15. https://doi.org/10.1038/s41514-024-00143-7

• Journal Article Type: Article
• Acceptance Date: Feb 14, 2024
• Online Publication Date: Feb 27, 2024
• Publication Date: 2024-02
• Deposit Date: Mar 5, 2024
• Publicly Available Date: Mar 5, 2024
• Journal: npj aging
• Electronic ISSN: 2731-6068
• Publisher: Nature Research
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• Article Number: 15
• DOI: https://doi.org/10.1038/s41514-024-00143-7
• Keywords: Biochemistry; Cardiovascular diseases
• Public URL: https://nottingham-repository.worktribe.com/output/32167530
• Publisher URL: https://www.nature.com/articles/s41514-024-00143-7
• PMID: 38413600