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Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Shek, Naomi; Choy, Anna-Maria; Lang, Chim C; Miller, Bruce E; Tal-Singer, Ruth; Bolton, Charlotte E; Thomson, Neil C; Chalmers, James D; Bown, Matt J; Newby, David E; Khan, Faisel; Huang, Jeffrey T J

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Authors

Naomi Shek

Anna-Maria Choy

Chim C Lang

Bruce E Miller

Ruth Tal-Singer

Neil C Thomson

James D Chalmers

Matt J Bown

David E Newby

Faisel Khan

Jeffrey T J Huang



Abstract

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

Citation

Shek, N., Choy, A., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., …Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), Article 15. https://doi.org/10.1038/s41514-024-00143-7

Journal Article Type Article
Acceptance Date Feb 14, 2024
Online Publication Date Feb 27, 2024
Publication Date 2024-02
Deposit Date Mar 5, 2024
Publicly Available Date Mar 5, 2024
Journal npj aging
Electronic ISSN 2731-6068
Publisher Nature Research
Peer Reviewed Peer Reviewed
Volume 10
Issue 1
Article Number 15
DOI https://doi.org/10.1038/s41514-024-00143-7
Keywords Biochemistry; Cardiovascular diseases
Public URL https://nottingham-repository.worktribe.com/output/32167530
Publisher URL https://www.nature.com/articles/s41514-024-00143-7
PMID 38413600

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