Naomi Shek
Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases
Shek, Naomi; Choy, Anna-Maria; Lang, Chim C; Miller, Bruce E; Tal-Singer, Ruth; Bolton, Charlotte E; Thomson, Neil C; Chalmers, James D; Bown, Matt J; Newby, David E; Khan, Faisel; Huang, Jeffrey T J
Authors
Anna-Maria Choy
Chim C Lang
Bruce E Miller
Ruth Tal-Singer
Professor CHARLOTTE BOLTON charlotte.bolton@nottingham.ac.uk
Professor of Respiratory Medicine
Neil C Thomson
James D Chalmers
Matt J Bown
David E Newby
Faisel Khan
Jeffrey T J Huang
Abstract
Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
Citation
Shek, N., Choy, A., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., …Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), Article 15. https://doi.org/10.1038/s41514-024-00143-7
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 14, 2024 |
Online Publication Date | Feb 27, 2024 |
Publication Date | 2024-02 |
Deposit Date | Mar 5, 2024 |
Publicly Available Date | Mar 5, 2024 |
Journal | npj aging |
Electronic ISSN | 2731-6068 |
Publisher | Nature Research |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Issue | 1 |
Article Number | 15 |
DOI | https://doi.org/10.1038/s41514-024-00143-7 |
Keywords | Biochemistry; Cardiovascular diseases |
Public URL | https://nottingham-repository.worktribe.com/output/32167530 |
Publisher URL | https://www.nature.com/articles/s41514-024-00143-7 |
PMID | 38413600 |
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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