Jeffrey Huang
Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases
Huang, Jeffrey; Shek, Naomi; Choy, Anna-Maria; Lang, Chim; Miller, Bruce; Tal-Singer, Ruth; Bolton, Charlotte; Thomson, Neil; Newby, David; Chalmers, James; Khan, Faisel; Brown, Matthew
Authors
Naomi Shek
Anna-Maria Choy
Chim Lang
Bruce Miller
Ruth Tal-Singer
Professor CHARLOTTE BOLTON charlotte.bolton@nottingham.ac.uk
Professor of Respiratory Medicine
Neil Thomson
David Newby
James Chalmers
Faisel Khan
Matthew Brown
Abstract
Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
Citation
Huang, J., Shek, N., Choy, A., Lang, C., Miller, B., Tal-Singer, R., …Brown, M. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases
Working Paper Type | Working Paper |
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Deposit Date | Feb 29, 2024 |
Publicly Available Date | Mar 5, 2024 |
Public URL | https://nottingham-repository.worktribe.com/output/27086594 |
Publisher URL | https://www.researchsquare.com/article/rs-3379154/v1 |
Additional Information | This is a preprint; it has not been peer reviewed by a journal. |
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Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases
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Licence
https://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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