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Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

Elneima, Omer; McAuley, Hamish J C; Leavy, Olivia C; Chalmers, James D; Horsley, Alex; Ho, Ling-Pei; Marks, Michael; Poinasamy, Krisnah; Raman, Betty; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Harris, Victoria C; Houchen-Wolloff, Linzy; Saunders, Ruth M; Greening, Neil J; Richardson, Matthew; Quint, Jennifer K; Briggs, Andrew; Docherty, Annemarie B; Kerr, Steven; Harrison, Ewen M; Lone, Nazir I; Thorpe, Mathew; Heaney, Liam G; Lewis, Keir E; Aul, Raminder; Beirne, Paul; Bolton, Charlotte E; Brown, Jeremy S; Choudhury, Gourab; Diar Bakerly, Nawar; Easom, Nicholas; Echevarria, Carlos; Fuld, Jonathan; Hart, Nick; Hurst, John R; Jones, Mark G; Parekh, Dhruv; Pfeffer, Paul E; Rahman, Najib M; Rowland-Jones, Sarah L; Thompson, AA Roger; Jolley, Caroline; Shah, Ajay M; Wootton, Dan G; Chalder, Trudie; Davies, Melanie J; De Soyza, Anthony; Geddes, John R; Greenhalf, William; Heller, Simon; Howard, Luke S; Jacob, Joseph; Jenkins, R Gisli; Lord, Janet M; Man, William D-C; McCann, Gerry...

Authors

Omer Elneima

Hamish J C McAuley

Olivia C Leavy

James D Chalmers

Alex Horsley

Ling-Pei Ho

Michael Marks

Krisnah Poinasamy

Betty Raman

Aarti Shikotra

Amisha Singapuri

Marco Sereno

Victoria C Harris

Linzy Houchen-Wolloff

Ruth M Saunders

Neil J Greening

Matthew Richardson

Jennifer K Quint

Andrew Briggs

Annemarie B Docherty

Steven Kerr

Ewen M Harrison

Nazir I Lone

Mathew Thorpe

Liam G Heaney

Keir E Lewis

Raminder Aul

Paul Beirne

Jeremy S Brown

Gourab Choudhury

Nawar Diar Bakerly

Nicholas Easom

Carlos Echevarria

Jonathan Fuld

Nick Hart

John R Hurst

Mark G Jones

Dhruv Parekh

Paul E Pfeffer

Najib M Rahman

Sarah L Rowland-Jones

AA Roger Thompson

Caroline Jolley

Ajay M Shah

Dan G Wootton

Trudie Chalder

Melanie J Davies

Anthony De Soyza

John R Geddes

William Greenhalf

Simon Heller

Luke S Howard

Joseph Jacob

R Gisli Jenkins

Janet M Lord

William D-C Man

Gerry P McCann

Stefan Neubauer

Peter JM Openshaw

Joanna C Porter

Matthew J Rowland

Janet T Scott

Malcolm G Semple

Sally J Singh

David C Thomas

Mark Toshner

Aziz Sheikh

Chris E Brightling

Louise v Wain

Rachael A Evans

on behalf of the PHOSP-COVID Collaborative Group



Abstract

PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged.

PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalisation, understand the underlying mechanisms of these sequelae, evaluate the medium- and long-term effects of COVID-19 treatments, and to serve as a platform to enable future studies, including clinical trials.

Data collected covered a wide range of physical measures, biological samples, and Patient Reported Outcome Measures (PROMs).

Participants could join the cohort either in Tier 1 only with remote data collection using hospital records, a PROMs app and postal saliva sample for DNA, or in Tier 2 where they were invited to attend two specific research visits for further data collection and biological research sampling. These research visits occurred at five (range 2-7) months and 12 (range 10-14) months post-discharge. Participants could also participate in specific nested studies (Tier 3) at selected sites.

All participants were asked to consent to further follow-up for 25 years via linkage to their electronic healthcare records and to be re-contacted for further research.

In total, 7935 participants were recruited from 83 UK sites: 5238 to Tier 1 and 2697 to Tier 2, between August 2020 and March 2022.

Cohort data are held in a Trusted Research Environment and samples stored in a central biobank. Data and samples can be accessed upon request and subject to approvals.

Citation

Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L.-P., Marks, M., Poinasamy, K., Raman, B., Shikotra, A., Singapuri, A., Sereno, M., Harris, V. C., Houchen-Wolloff, L., Saunders, R. M., Greening, N. J., Richardson, M., Quint, J. K., Briggs, A., Docherty, A. B., …on behalf of the PHOSP-COVID Collaborative Group. Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

Working Paper Type Working Paper
Deposit Date Feb 29, 2024
Publicly Available Date Feb 29, 2024
Public URL https://nottingham-repository.worktribe.com/output/20566993
Publisher URL https://www.medrxiv.org/content/10.1101/2023.05.08.23289442v1

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