Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

Elneima, Omer; McAuley, Hamish J C; Leavy, Olivia C; Chalmers, James D; Horsley, Alex; Ho, Ling-Pei; Marks, Michael; Poinasamy, Krisnah; Raman, Betty; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Harris, Victoria C; Houchen-Wolloff, Linzy; Saunders, Ruth M; Greening, Neil J; Richardson, Matthew; Quint, Jennifer K; Briggs, Andrew; Docherty, Annemarie B; Kerr, Steven; Harrison, Ewen M; Lone, Nazir I; Thorpe, Mathew; Heaney, Liam G; Lewis, Keir E; Aul, Raminder; Beirne, Paul; Bolton, Charlotte E; Brown, Jeremy S; Choudhury, Gourab; Diar Bakerly, Nawar; Easom, Nicholas; Echevarria, Carlos; Fuld, Jonathan; Hart, Nick; Hurst, John R; Jones, Mark G; Parekh, Dhruv; Pfeffer, Paul E; Rahman, Najib M; Rowland-Jones, Sarah L; Thompson, AA Roger; Jolley, Caroline; Shah, Ajay M; Wootton, Dan G; Chalder, Trudie; Davies, Melanie J; De Soyza, Anthony; Geddes, John R; Greenhalf, William; Heller, Simon; Howard, Luke S; Jacob, Joseph; Jenkins, R Gisli; Lord, Janet M; Man, William D-C; McCann, Gerry P; Neubauer, Stefan; Openshaw, Peter JM; Porter, Joanna C; Rowland, Matthew J; Scott, Janet T; Semple, Malcolm G; Singh, Sally J; Thomas, David C; Toshner, Mark; Sheikh, Aziz; Brightling, Chris E; Wain, Louise v; Evans, Rachael A; on behalf of the PHOSP-COVID Collaborative Group

Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

Elneima, Omer; McAuley, Hamish J C; Leavy, Olivia C; Chalmers, James D; Horsley, Alex; Ho, Ling-Pei; Marks, Michael; Poinasamy, Krisnah; Raman, Betty; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Harris, Victoria C; Houchen-Wolloff, Linzy; Saunders, Ruth M; Greening, Neil J; Richardson, Matthew; Quint, Jennifer K; Briggs, Andrew; Docherty, Annemarie B; Kerr, Steven; Harrison, Ewen M; Lone, Nazir I; Thorpe, Mathew; Heaney, Liam G; Lewis, Keir E; Aul, Raminder; Beirne, Paul; Bolton, Charlotte E; Brown, Jeremy S; Choudhury, Gourab; Diar Bakerly, Nawar; Easom, Nicholas; Echevarria, Carlos; Fuld, Jonathan; Hart, Nick; Hurst, John R; Jones, Mark G; Parekh, Dhruv; Pfeffer, Paul E; Rahman, Najib M; Rowland-Jones, Sarah L; Thompson, AA Roger; Jolley, Caroline; Shah, Ajay M; Wootton, Dan G; Chalder, Trudie; Davies, Melanie J; De Soyza, Anthony; Geddes, John R; Greenhalf, William; Heller, Simon; Howard, Luke S; Jacob, Joseph; Jenkins, R Gisli; Lord, Janet M; Man, William D-C; McCann, Gerry...

Authors

Omer Elneima

Hamish J C McAuley

Olivia C Leavy

James D Chalmers

Alex Horsley

Ling-Pei Ho

Michael Marks

Krisnah Poinasamy

Betty Raman

Aarti Shikotra

Amisha Singapuri

Marco Sereno

Victoria C Harris

Linzy Houchen-Wolloff

Ruth M Saunders

Neil J Greening

Matthew Richardson

Jennifer K Quint

Andrew Briggs

Annemarie B Docherty

Steven Kerr

Ewen M Harrison

Nazir I Lone

Mathew Thorpe

Liam G Heaney

Keir E Lewis

Raminder Aul

Paul Beirne

Professor CHARLOTTE BOLTON charlotte.bolton@nottingham.ac.uk
Professor of Respiratory Medicine

Jeremy S Brown

Gourab Choudhury

Nawar Diar Bakerly

Nicholas Easom

Carlos Echevarria

Jonathan Fuld

Nick Hart

John R Hurst

Mark G Jones

Dhruv Parekh

Paul E Pfeffer

Najib M Rahman

Sarah L Rowland-Jones

AA Roger Thompson

Caroline Jolley

Ajay M Shah

Dan G Wootton

Trudie Chalder

Melanie J Davies

Anthony De Soyza

John R Geddes

William Greenhalf

Simon Heller

Luke S Howard

Joseph Jacob

R Gisli Jenkins

Janet M Lord

William D-C Man

Gerry P McCann

Stefan Neubauer

Peter JM Openshaw

Joanna C Porter

Matthew J Rowland

Janet T Scott

Malcolm G Semple

Sally J Singh

David C Thomas

Mark Toshner

Aziz Sheikh

Chris E Brightling

Louise v Wain

Rachael A Evans

on behalf of the PHOSP-COVID Collaborative Group

Abstract

PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged.

PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalisation, understand the underlying mechanisms of these sequelae, evaluate the medium- and long-term effects of COVID-19 treatments, and to serve as a platform to enable future studies, including clinical trials.

Data collected covered a wide range of physical measures, biological samples, and Patient Reported Outcome Measures (PROMs).

Participants could join the cohort either in Tier 1 only with remote data collection using hospital records, a PROMs app and postal saliva sample for DNA, or in Tier 2 where they were invited to attend two specific research visits for further data collection and biological research sampling. These research visits occurred at five (range 2-7) months and 12 (range 10-14) months post-discharge. Participants could also participate in specific nested studies (Tier 3) at selected sites.

All participants were asked to consent to further follow-up for 25 years via linkage to their electronic healthcare records and to be re-contacted for further research.

In total, 7935 participants were recruited from 83 UK sites: 5238 to Tier 1 and 2697 to Tier 2, between August 2020 and March 2022.

Cohort data are held in a Trusted Research Environment and samples stored in a central biobank. Data and samples can be accessed upon request and subject to approvals.

Deposit Date	Feb 29, 2024
Publicly Available Date	Feb 29, 2024
Public URL	https://nottingham-repository.worktribe.com/output/20566993
Publisher URL	https://www.medrxiv.org/content/10.1101/2023.05.08.23289442v1