Omer Elneima
Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)
Elneima, Omer; McAuley, Hamish J C; Leavy, Olivia C; Chalmers, James D; Horsley, Alex; Ho, Ling-Pei; Marks, Michael; Poinasamy, Krisnah; Raman, Betty; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Harris, Victoria C; Houchen-Wolloff, Linzy; Saunders, Ruth M; Greening, Neil J; Richardson, Matthew; Quint, Jennifer K; Briggs, Andrew; Docherty, Annemarie B; Kerr, Steven; Harrison, Ewen M; Lone, Nazir I; Thorpe, Mathew; Heaney, Liam G; Lewis, Keir E; Aul, Raminder; Beirne, Paul; Bolton, Charlotte E; Brown, Jeremy S; Choudhury, Gourab; Diar Bakerly, Nawar; Easom, Nicholas; Echevarria, Carlos; Fuld, Jonathan; Hart, Nick; Hurst, John R; Jones, Mark G; Parekh, Dhruv; Pfeffer, Paul E; Rahman, Najib M; Rowland-Jones, Sarah L; Thompson, AA Roger; Jolley, Caroline; Shah, Ajay M; Wootton, Dan G; Chalder, Trudie; Davies, Melanie J; De Soyza, Anthony; Geddes, John R; Greenhalf, William; Heller, Simon; Howard, Luke S; Jacob, Joseph; Jenkins, R Gisli; Lord, Janet M; Man, William D-C; McCann, Gerry...
Authors
Hamish J C McAuley
Olivia C Leavy
James D Chalmers
Alex Horsley
Ling-Pei Ho
Michael Marks
Krisnah Poinasamy
Betty Raman
Aarti Shikotra
Amisha Singapuri
Marco Sereno
Victoria C Harris
Linzy Houchen-Wolloff
Ruth M Saunders
Neil J Greening
Matthew Richardson
Jennifer K Quint
Andrew Briggs
Annemarie B Docherty
Steven Kerr
Ewen M Harrison
Nazir I Lone
Mathew Thorpe
Liam G Heaney
Keir E Lewis
Raminder Aul
Paul Beirne
Professor CHARLOTTE BOLTON charlotte.bolton@nottingham.ac.uk
Professor of Respiratory Medicine
Jeremy S Brown
Gourab Choudhury
Nawar Diar Bakerly
Nicholas Easom
Carlos Echevarria
Jonathan Fuld
Nick Hart
John R Hurst
Mark G Jones
Dhruv Parekh
Paul E Pfeffer
Najib M Rahman
Sarah L Rowland-Jones
AA Roger Thompson
Caroline Jolley
Ajay M Shah
Dan G Wootton
Trudie Chalder
Melanie J Davies
Anthony De Soyza
John R Geddes
William Greenhalf
Simon Heller
Luke S Howard
Joseph Jacob
R Gisli Jenkins
Janet M Lord
William D-C Man
Gerry P McCann
Stefan Neubauer
Peter JM Openshaw
Joanna C Porter
Matthew J Rowland
Janet T Scott
Malcolm G Semple
Sally J Singh
David C Thomas
Mark Toshner
Aziz Sheikh
Chris E Brightling
Louise v Wain
Rachael A Evans
on behalf of the PHOSP-COVID Collaborative Group
Abstract
PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged.
PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalisation, understand the underlying mechanisms of these sequelae, evaluate the medium- and long-term effects of COVID-19 treatments, and to serve as a platform to enable future studies, including clinical trials.
Data collected covered a wide range of physical measures, biological samples, and Patient Reported Outcome Measures (PROMs).
Participants could join the cohort either in Tier 1 only with remote data collection using hospital records, a PROMs app and postal saliva sample for DNA, or in Tier 2 where they were invited to attend two specific research visits for further data collection and biological research sampling. These research visits occurred at five (range 2-7) months and 12 (range 10-14) months post-discharge. Participants could also participate in specific nested studies (Tier 3) at selected sites.
All participants were asked to consent to further follow-up for 25 years via linkage to their electronic healthcare records and to be re-contacted for further research.
In total, 7935 participants were recruited from 83 UK sites: 5238 to Tier 1 and 2697 to Tier 2, between August 2020 and March 2022.
Cohort data are held in a Trusted Research Environment and samples stored in a central biobank. Data and samples can be accessed upon request and subject to approvals.
Deposit Date | Feb 29, 2024 |
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Publicly Available Date | Feb 29, 2024 |
Public URL | https://nottingham-repository.worktribe.com/output/20566993 |
Publisher URL | https://www.medrxiv.org/content/10.1101/2023.05.08.23289442v1 |
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Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)
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Licence
https://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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