All Outputs (20)

Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease (2021)
Journal Article
Bourgognon, J., Spiers, J. G., Robinson, S. W., Scheiblich, H., Glynn, P., Ortori, C., …Steinert, J. R. (2021). Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease. Proceedings of the National Academy of Sciences, 118(10), Article e2009579118. https://doi.org/10.1073/pnas.2009579118

Several neurodegenerative diseases associated with protein misfolding (Alzheimer’s and Parkinson’s disease) exhibit oxidative and nitrergic stress following initiation of neuroinflammatory pathways. Associated nitric oxide (NO)-mediated posttranslati... Read More about Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease.

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article
Scott, R. A., Williams, H. G., Hoad, C. L., Alyami, A., Ortori, C. A., Grove, J. I., …Gowland, P. A. (2021). MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability. Journal of Magnetic Resonance Imaging, 53(5), 1422-1431. https://doi.org/10.1002/jmri.27463

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.

Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome (2019)
Journal Article
Sander, K. N., Kim, D., Ortori, C. A., Warren, A. Y., Anyanwagu, U. C., Hay, D. P., …Barrett, D. A. (2019). Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome. Metabolomics, 15, 1-10. https://doi.org/10.1007/s11306-019-1600-8

Introduction Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies. Objectives As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored unde... Read More about Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin (2019)
Journal Article
Lee, J. B., Radhi, M., Cipolla, E., Gandhi, R. D., Sarmad, S., Zgair, A., …Gershkovich, P. (2019). A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin. Scientific Reports, 9, Article 15760. https://doi.org/10.1038/s41598-019-52254-x

Although adenosine and its analogues have been assessed in the past as potential drug candidates due to the important role of adenosine in physiology, only little is known about their absorption following oral administration. In this work, we have st... Read More about A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin.

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats (2019)
Journal Article
Pollard, A. K., Ingram, T. L., Ortori, C. A., Shephard, F., Brown, M., Liddell, S., …Chakrabarti, L. (2019). A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. Aging, 11(6), 1664-1685. https://doi.org/10.18632/aging.101861

It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over... Read More about A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats.

An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers (2018)
Journal Article
Stone, N. L., Millar, S. A., Herrod, P. J. J., Barrett, D. A., Ortori, C. A., Mellon, V. A., & O’Sullivan, S. E. (2018). An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers. Frontiers in Behavioral Neuroscience, 12, 1-10. https://doi.org/10.3389/fnbeh.2018.00269

© 2018 Stone, Millar, Herrod, Barrett, Ortori, Mellon and O’Sullivan. The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appe... Read More about An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers.

n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids (2018)
Journal Article
Alharthi, N., Christensen, P., Hourani, W., Ortori, C., Barrett, D. A., Bennett, A. J., …Alexander, S. P. (2018). n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1863(11), 1433-1440. https://doi.org/10.1016/j.bbalip.2018.08.003

Anandamide, the first identified endogenous cannabinoid and TRPV1 agonist, is one of a series of endogenous N-acylethanolamines, NAEs. We have generated novel assays to quantify the levels of multiple NAEs in biological tissues and their rates of hyd... Read More about n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids.

The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells (2017)
Journal Article
Schlosser, M., Löser, H., Siegmund, S. V., Montesinos-Rongen, M., Bindila, L., Lutz, B., …Fries, J. W. (2017). The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells. CellBio, 6(4), 35-55. https://doi.org/10.4236/cellbio.2017.64004

Background: The endocannabinoid (EC) system is well characterized in the central nervous system but scarcely studied in peripheral organs. In this paper, we newly identify the effect of the EC anandamide (AEA) upon renal proximal tubule cells. Meth... Read More about The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells.

Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development (2017)
Journal Article
H-T. Kwok, C., Devonshire, I. M., Imraish, A., Greenspon, C. M., Lockwood, S., Fielden, C., …Hathway, G. J. (2017). Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. PAIN, 158(11), 2222-2232. https://doi.org/10.1097/j.pain.0000000000001027

Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which mod... Read More about Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.

A metabolomic analytical approach permits identification of urinary biomarkers for Plasmodium falciparum infection: a case–control study (2017)
Journal Article
Abdelrazig, S. M., Ortori, C. A., Davey, G., Deressa, W., Mulleta, D., Barrett, D. A., …Fogarty, A. W. (2017). A metabolomic analytical approach permits identification of urinary biomarkers for Plasmodium falciparum infection: a case–control study. Malaria Journal, 16, Article 229. https://doi.org/10.1186/s12936-017-1875-z

BACKGROUND: Currently available diagnostic techniques of Plasmodium falciparum infection are not optimal for non-invasive, population-based screening for malaria. It was hypothesized that a mass spectrometry-based metabolomics approach could identify... Read More about A metabolomic analytical approach permits identification of urinary biomarkers for Plasmodium falciparum infection: a case–control study.

Mouse mitochondrial lipid composition is defined by age in brain and muscle (2017)
Journal Article
Pollard, A. K., Ortori, C. A., Stöger, R., Barrett, D. A., & Chakrabarti, L. (in press). Mouse mitochondrial lipid composition is defined by age in brain and muscle. Aging, 9(3), https://doi.org/10.18632/aging.101204

Functionality of the lipid rich mitochondrial organelle declines with increased age. Recent advances in lipidomic technologies allowed us to perform a global characterisation of lipid composition in two different tissue types and age ranges. Ultra-hi... Read More about Mouse mitochondrial lipid composition is defined by age in brain and muscle.

The fitness burden imposed by synthesising quorum sensing signals (2016)
Journal Article
Ruparell, A., Dubern, J., Ortori, C. A., Harrison, F., Halliday, N., Emtage, A., …Hardie, K. R. (2016). The fitness burden imposed by synthesising quorum sensing signals. Scientific Reports, 6, Article 33101. https://doi.org/10.1038/srep33101

It is now well established that bacterial populations utilize cell-to-cell signaling (quorum-sensing, QS) to control the production of public goods and other co-operative behaviours. Evolutionary theory predicts that both the cost of signal productio... Read More about The fitness burden imposed by synthesising quorum sensing signals.

Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis? (2015)
Journal Article
Bayston, R., Ashraf, W., & Ortori, C. (2015). Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis?. Journal of Neurosurgery, 124(2), https://doi.org/10.3171/2014.12.JNS141900

OBJECT Recently concern has arisen over the effect of released antimicrobial agents from antibiotic-impregnated external ventricular drainage (EVD) catheters on the reliability of CSF culture for diagnosis of ventriculitis. The authors designed a... Read More about Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis?.

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity (2015)
Journal Article
Halliday, M., Ortori, C., Radford, H., Barrett, D., Sekine, Y., Fischer, P., …Mallucci, G. (2015). Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death and Disease, 6, https://doi.org/10.1038/cddis.2015.49

© 2015 Macmillan Publishers Limited All rights reserved. Activation of the PERK branch of the unfolded protein response (UPR) in response to protein misfolding within the endoplasmic reticulum (ER) results in the transient repression of protein synth... Read More about Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation (2014)
Journal Article
Stephens, F. B., Mendis, B., Shannon, C. E., Cooper, S., Ortori, C. A., Barrett, D. A., …Tsintzas, K. (2014). Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation. Clinical Science, 127(5), 315-322. https://doi.org/10.1042/cs20140031

Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced i... Read More about Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation.

A strategy for characterization of triterpene saponins in Caulophyllum robustum hairy roots by liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry (2014)
Journal Article
Xia, Y., Barrett, D., Li, G., Ortori, C., Liang, J., Yang, B., & Kuang, H. (2014). A strategy for characterization of triterpene saponins in Caulophyllum robustum hairy roots by liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 100, doi:10.1016/j.jpba.2014.07.024

Triterpene saponins are important bioactive constituents widely distributed in many plants. Saponins present in Caulophyllum (Berberidaceae) have not been fully characterized. In this study, we studied triterpene saponins from Caulophyllum robustum u... Read More about A strategy for characterization of triterpene saponins in Caulophyllum robustum hairy roots by liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry.

Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis (2014)
Journal Article
Wong, A., Sagar, D. R., Ortori, C. A., Kendall, D. A., Chapman, V., & Barrett, D. A. (2014). Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis. Journal of Lipid Research, 55(9), 1902-1913. doi:10.1194/jlr.M048694

We describe a novel LC method for the simultaneous and quantitative profiling of 43 oxylipins including eicosanoids, endocannabinoids, and structurally related bioactive lipids with modified acyl groups. The LC-MS/MS method uses switching at a define... Read More about Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis.

Corrigendum: Sustained translational repression by eIF2 alpha-P mediates prion neurodegeneration (vol 485, pg 507, 2012) (2014)
Journal Article
Moreno, J. A., Radford, H., Peretti, D., Steinert, J. R., Verity, N., Guerra Martin, M., …Mallucci, G. R. (2014). Corrigendum: Sustained translational repression by eIF2 alpha-P mediates prion neurodegeneration (vol 485, pg 507, 2012). Nature, 511(7509), https://doi.org/10.1038/nature13569

LC-MS/MS Quantitative Analysis of Quorum Sensing Signal Molecules (2014)
Book Chapter
Ortori, C. A., Ortori, C., Halliday, N., Cámara, M., Williams, P., & Barrett, D. A. (2014). LC-MS/MS Quantitative Analysis of Quorum Sensing Signal Molecules. In A. Filloux, & J. Ramos (Eds.), Pseudomonas Methods and Protocols (255-270). Springer. https://doi.org/10.1007/978-1-4939-0473-0_21

© Springer Science+Business Media New York 2014. Extracts taken from spent growth media from Pseudomonas aeruginosa can be analyzed for N -acyl- L - homoserine lactones and 2-alkyl-4-(1 H)-quinolones (AQs), including the known quorum sensing signalli... Read More about LC-MS/MS Quantitative Analysis of Quorum Sensing Signal Molecules.

Sustained translational repression by eIF2?-P mediates prion neurodegeneration (2012)
Journal Article
Moreno, J. A., Radford, H., Peretti, D., Steinert, J. R., Verity, N., Martin, M. G., …Mallucci, G. R. (2012). Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature, 485(7399), 507-511. https://doi.org/10.1038/nature11058

The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer's, Parkinson's and prion diseases, are associated with the accumulation of misfolded disease-specific proteins.... Read More about Sustained translational repression by eIF2?-P mediates prion neurodegeneration.