All Outputs (136)

Multiscale modelling of drug-polymer nanoparticle assembly identifies parameters influencing drug encapsulation efficiency (2015)
Journal Article

Using a multiscale (dual resolution) approach combining an atomistic (GROMOS96) and coarse-grain (MARTINI) force field, we have been able to simulate the process of drug-polymer nanoparticle assembly by nanoprecipitation from mixed solvents. Here we... Read More about Multiscale modelling of drug-polymer nanoparticle assembly identifies parameters influencing drug encapsulation efficiency.

Triblock copolymer nanovesicles for pH-responsive targeted delivery and controlled release of siRNA to cancer cells (2015)
Journal Article

New pH-responsive polymersomes for active anticancer oligonucleotide delivery were prepared from triblock copolymers. The delivery systems were formed by two terminal hydrophilic blocks, PEG and polyglycerolmethacrylate (poly-GMA), and a central weak... Read More about Triblock copolymer nanovesicles for pH-responsive targeted delivery and controlled release of siRNA to cancer cells.

Multifunctional poly[N-(2-hydroxypropyl)methacrylamide] copolymers via postpolymerization modification and sequential thiol–ene chemistry (2015)
Journal Article

Poly[N-(2-hydroxypropyl)methacrylamide] is a promising candidate material for biomedical applications. However, synthesis of functional pHPMA via compolymerization results can lead to variations in monomer composition, molar mass, and dispersity maki... Read More about Multifunctional poly[N-(2-hydroxypropyl)methacrylamide] copolymers via postpolymerization modification and sequential thiol–ene chemistry.

In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment (2015)
Journal Article

Physiologically relevant in vitro models can serve as biological analytical platforms for testing novel treatments and drug delivery systems. We describe the first steps in the development of a 3D human brain tumour co-culture model that includes the... Read More about In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment.

A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration (2014)
Journal Article

A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postcult... Read More about A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration.

Camptothecin prodrug block copolymer micelles with high drug loading and target specificity (2014)
Journal Article

The clinical efficacy of cytotoxic drugs in the treatment of cancer is often hampered by poor pharmacodynamics and systemic toxicity. Here, we describe the design and synthesis of a new PEG-based system for the delivery of the cytotoxic camptothecin... Read More about Camptothecin prodrug block copolymer micelles with high drug loading and target specificity.

Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling (2014)
Journal Article

The detection and inactivation of pathogenic strains of bacteria continues to be an important therapeutic goal. Hence, there is a need for materials that can bind selectively to specific microorganisms for diagnostic or anti-infective applications, b... Read More about Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling.

Programmed assembly of polymer–DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition (2014)
Journal Article

Soft micellar nanoparticles can be prepared from DNA conjugates designed to assemble via base pairing such that strands containing a polymer corona and a cholesterol tail generate controlled supramolecular architecture. Functionalization of one DNA c... Read More about Programmed assembly of polymer–DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition.

Multimodal Polymer Nanoparticles with Combined 19F Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo (2014)
Journal Article

Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres (2014)
Journal Article

Three-dimensional cell culture has many advantages over monolayer cultures, and spheroids have been hailed as the best current representation of small avascular tumours in vitro. However their adoption in regular screening programs has been hindered... Read More about Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres.

Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes (2013)
Journal Article

Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one mean by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can... Read More about Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes.

Uptake and transport of B12-conjugated nanoparticles in airway epithelium (2013)
Journal Article

Non-invasive delivery of biotherapeutics, as an attractive alternative to injections, could potentially be achieved through the mucosal surfaces, utilizing nanoscale therapeutic carriers. However, nanoparticles do not readily cross the mucosal barrie... Read More about Uptake and transport of B12-conjugated nanoparticles in airway epithelium.

Nanoparticle transport in epithelial cells: pathway switching through bioconjugation (2013)
Journal Article

The understanding and control of nanoparticle transport into and through cellular compartments is central to biomedical applications of nanotechnology. Here, it is shown that the transport pathway of 50 nm polystyrene nanoparticles decorated with vit... Read More about Nanoparticle transport in epithelial cells: pathway switching through bioconjugation.

Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line (2013)
Journal Article

Polymer particles consisting of a biodegradable poly[lactide-co-glycolide] (PLGA) core and a thermoresponsive shell have been formulated to encapsulate the dye rhodamine 6G and the potent cytotoxic drug paclitaxel. Cellular uptake of these particles... Read More about Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line.

Thermoresponsive polymer colloids for drug delivery and cancer therapy (2011)
Journal Article

Many difficulties in treating cancer arise from the problems in directing highly cytotoxic agents to the deseased tissues, cells and intracellular compartments. Many drug delivery systems have been devised to address this problem, including those tha... Read More about Thermoresponsive polymer colloids for drug delivery and cancer therapy.

Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents (2009)
Journal Article

Responsive polymeric nanoparticles composed of hybrid block co-polymers were prepared from biocompatible components that displayed rapid, tunable and multiply reversible transitions in response to change of temperature. © 2009 The Royal Society of Ch... Read More about Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents.