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Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes

Lui, Leong T.; Xue, Xuan; Sui, Cheng; Brown, Alan; Pritchard, David I.; Halliday, Nigel; Winzer, Klaus; Howdle, Stephen M.; Fernandez-Trillo, Francisco; Krasnogor, Natalio; Alexander, Cameron

Authors

Leong T. Lui

Xuan Xue

Cheng Sui

Alan Brown

David I. Pritchard

Nigel Halliday

Klaus Winzer klaus.winzer@nottingham.ac.uk

Stephen M. Howdle

Francisco Fernandez-Trillo

Natalio Krasnogor

Cameron Alexander cameron.alexander@notingham.ac.uk



Abstract

Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one mean by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical reactions used for quorum sensing are thus a potential means to control bacterial population responses. Here we report how polymeric "bacteria sequestrants", designed to bind to bacteria through electrostatic interactions and thus inhibit bacterial adhesion to surfaces, induce the expression of quorum sensing controlled phenotypes as a consequence of cell clustering. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterise the feedback between bacteria clustering and quorum sensing signaling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level

Journal Article Type Article
Publication Date Dec 1, 2013
Journal Nature Chemistry
Print ISSN 1755-4330
Electronic ISSN 1755-4349
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 5
Issue 12
APA6 Citation Lui, L. T., Xue, X., Sui, C., Brown, A., Pritchard, D. I., Halliday, N., …Alexander, C. (2013). Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes. Nature Chemistry, 5(12), doi:10.1038/nchem.1793
DOI https://doi.org/10.1038/nchem.1793
Keywords Polymers, bacteria, quorum sensing, molecular recognition, synthetic biology
Publisher URL http://www.nature.com/nchem/journal/v5/n12/full/nchem.1793.html
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information nchem.1793

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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