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All Outputs (20)

Inverse association between blood pressure and pulse oximetry accuracy: an observational study in patients with suspected or confirmed COVID-19 infection (2022)
Journal Article

Background Pulse oximeters are a standard non-invasive tool to measure blood oxygen levels, and are used in multiple healthcare settings. It is important to understand the factors affecting their accuracy to be able to use them optimally and safely.... Read More about Inverse association between blood pressure and pulse oximetry accuracy: an observational study in patients with suspected or confirmed COVID-19 infection.

Differential pulse oximetry readings between ethnic groups and delayed transfer to intensive care units (2022)
Journal Article

Summary Background Pulse oximeters are widely used to monitor blood oxygen saturations, although concerns exist that they are less accurate in individuals with pigmented skin. Aims This study aimed to determine if patients with pigmented skin were mo... Read More about Differential pulse oximetry readings between ethnic groups and delayed transfer to intensive care units.

Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection (2022)
Journal Article

Objective To determine the maximal response of the temperature and inflammatory response to SARS-CoV-2 infection and how these are modified by age. Methods Participants were patients admitted to hospital with SARS-CoV-2 infection. For each partici... Read More about Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection.

Patients' attitudes towards cost feedback to doctors to prevent unnecessary testing: a qualitative focus group study (2020)
Journal Article

© 2020 The Authors Objectives: There is a need to improve efficiency in healthcare delivery without compromising quality of care. One approach is the development and evaluation of behavioural strategies to reduce unnecessary use of common tests. Howe... Read More about Patients' attitudes towards cost feedback to doctors to prevent unnecessary testing: a qualitative focus group study.

Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study (2020)
Journal Article

BACKGROUND: Avoidable use of diagnostic tests can both harm patients and increase the cost of healthcare. Nudge-type educational interventions have potential to modify clinician behaviour while respecting clinical autonomy and responsibility, but the... Read More about Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.

Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study (2019)
Journal Article

Background: In the context of increasing availability of computed tomography (CT) scans, judicious use of ionising radiation is a priority to minimise the risk of future health problems. Hence, education of clinicians on the risks and benefits of CT... Read More about Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study.

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More about Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study (2019)
Journal Article

Background: Behavioural insights or ‘nudge’ theory suggests that non-directional interventions may be used to modify human behaviour. We have tested the hypothesis that the provision of the cost of common blood tests with their results may modify sub... Read More about Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study.

Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study (2019)
Journal Article

Computerised tomography (CT) is readily available in developed countries. As one of the side-effects includes an increased risk of cancer, interventions that may encourage more judicious use of CT scans are important. Behavioural economics theory inc... Read More about Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study.

Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study (2016)
Journal Article

Background Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P. aeruginosa 2-alkyl-4-quinolones are det... Read More about Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study.

Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis (2015)
Journal Article

Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that ora... Read More about Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis.

The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study (2013)
Journal Article

Background Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder of aberrant blood vessel development characterised by arteriovenous malformations. HHT is associated with significant morbidity due to complications inc... Read More about The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study.