All Outputs (13)

Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing (2022)
Journal Article
Latif, A., Fisher, L. E., Dundas, A. A., Crucitti, V. C., Imir, Z., Lawler, K., …Ghaemmaghami, A. M. (2022). Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing. Advanced Materials, Article 2208364. https://doi.org/10.1002/adma.202208364

Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell type involv... Read More about Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing.

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals (2022)
Journal Article
Jaago, M., Rähni, A., Pupina, N., Pihlak, A., Sadam, H., Tuvikene, J., …Palm, K. (2022). Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals. Scientific Reports, 12(1), Article 16817. https://doi.org/10.1038/s41598-022-20849-6

Immunity to previously encountered viruses can alter response to unrelated pathogens. We reasoned that similar mechanism may also involve SARS-CoV-2 and thereby affect the specificity and the quality of the immune response against the virus. Here, we... Read More about Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals.

Correction to “Facile Dye-Initiated Polymerization of Lactide−Glycolide Generates Highly Fluorescent Poly(lactic-coglycolic Acid) for Enhanced Characterization of Cellular Delivery” (2022)
Journal Article
Yousif, M. D., Al-Natour, M. A., Cavanagh, R., Abouselo, A., Apebende, E. A., Ghaemmaghami, A., …Alexander, C. (2022). Correction to “Facile Dye-Initiated Polymerization of Lactide−Glycolide Generates Highly Fluorescent Poly(lactic-coglycolic Acid) for Enhanced Characterization of Cellular Delivery”. ACS Macro Letters, 11, 1224. https://doi.org/10.1021/acsmacrolett.2c00570

There is a change to the order of authorship for this published Letter. The author list should appear as it does in this Addition and Correction. All authors have agreed to this change.

Metabolic Signatures of Surface-Modified Poly(lactic- co-glycolic acid) Nanoparticles in Differentiated THP-1 Cells Derived with Liquid Chromatography-Mass Spectrometry-based Metabolomics (2022)
Journal Article
Al-Natour, M. A., Abdelrazig, S., Ghaemmaghami, A. M., Alexander, C., & Kim, D. H. (2022). Metabolic Signatures of Surface-Modified Poly(lactic- co-glycolic acid) Nanoparticles in Differentiated THP-1 Cells Derived with Liquid Chromatography-Mass Spectrometry-based Metabolomics. ACS Omega, https://doi.org/10.1021/acsomega.2c01660

Polymeric nanoparticles (NPs) are widely used in preclinical drug delivery investigations, and some formulations are now in the clinic. However, the detailed effects of many NPs at the subcellular level have not been fully investigated. In this study... Read More about Metabolic Signatures of Surface-Modified Poly(lactic- co-glycolic acid) Nanoparticles in Differentiated THP-1 Cells Derived with Liquid Chromatography-Mass Spectrometry-based Metabolomics.

Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration (2022)
Journal Article
Hasan, A., Bagnol, R., Owen, R., Latif, A., Rostam, H. M., Elsharkawy, S., …Mata, A. (2022). Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration. Frontiers in Bioengineering and Biotechnology, 10, Article 836386. https://doi.org/10.3389/fbioe.2022.836386

Design and fabrication of implants that can perform better than autologous bone grafts remain an unmet challenge for the hard tissue regeneration in craniomaxillofacial applications. Here, we report an integrated approach combining additive manufactu... Read More about Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration.

New Microfluidic System for Electrochemical Impedance Spectroscopy Assessment of Cell Culture Performance: Design and Development of New Electrode Material (2022)
Journal Article
Chmayssem, A., Tanase, C. E., Verplanck, N., Gougis, M., Mourier, V., Zebda, A., …Mailley, P. (2022). New Microfluidic System for Electrochemical Impedance Spectroscopy Assessment of Cell Culture Performance: Design and Development of New Electrode Material. Biosensors, 12(7), Article 452. https://doi.org/10.3390/bios12070452

Electrochemical impedance spectroscopy (EIS) is widely accepted as an effective and non-destructive method to assess cell health during cell-culture. However, there is a lack of compact devices compatible with microfluidic integration and microscopy... Read More about New Microfluidic System for Electrochemical Impedance Spectroscopy Assessment of Cell Culture Performance: Design and Development of New Electrode Material.

Single-Cell Metabolic Profiling of Macrophages Using 3D OrbiSIMS: Correlations with Phenotype (2022)
Journal Article
Suvannapruk, W., Edney, M. K., Kim, D., Scurr, D. J., Ghaemmaghami, A. M., & Alexander, M. R. (2022). Single-Cell Metabolic Profiling of Macrophages Using 3D OrbiSIMS: Correlations with Phenotype. Analytical Chemistry, 94(26), 9389–9398. https://doi.org/10.1021/acs.analchem.2c01375

Macrophages are important immune cells that respond to environmental cues acquiring a range of activation statuses represented by pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes at each end of their spectrum. Characterizing the metabolic... Read More about Single-Cell Metabolic Profiling of Macrophages Using 3D OrbiSIMS: Correlations with Phenotype.

Basement membrane properties and their recapitulation in organ-on-chip applications (2022)
Journal Article
Salimbeigi, G., Vrana, N. E., Ghaemmaghami, A. M., Huri, P. Y., & McGuinness, G. B. (2022). Basement membrane properties and their recapitulation in organ-on-chip applications. Materials Today Bio, 15, Article 100301. https://doi.org/10.1016/j.mtbio.2022.100301

Drug discovery and toxicology is a complex process that involves considerable basic research and preclinical evaluation. These depend highly on animal testing which often fails to predict human trial outcomes due to species differences. Coupled with... Read More about Basement membrane properties and their recapitulation in organ-on-chip applications.

Experimental Investigation of a MopFan-Based Photocatalytic Air Purification Device (2022)
Journal Article
Tapia-Brito, E., Riffat, J., Wang, Y., Ghaemmaghami, A. M., Coleman, C. M., & Riffat, S. (2022). Experimental Investigation of a MopFan-Based Photocatalytic Air Purification Device. Future Cities and Environment, 8(1), https://doi.org/10.5334/fce.149

Photocatalytic oxidation (PCO) is a potential approach for air cleaning, especially when utilising titanium dioxide (TiO2). A MopFan is similar to a roller brush but is made of flexible fibres coated with TiO2. Unlike conventional filter/mesh UV syst... Read More about Experimental Investigation of a MopFan-Based Photocatalytic Air Purification Device.

Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies (2022)
Journal Article
Rähni, A., Jaago, M., Sadam, H., Pupina, N., Pihlak, A., Tuvikene, J., …Palm, K. (2022). Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies. Communications Medicine, 2(1), Article 48. https://doi.org/10.1038/s43856-022-00114-7

Background: Immunotherapies, including cancer vaccines and immune checkpoint inhibitors have transformed the management of many cancers. However, a large number of patients show resistance to these immunotherapies and current research has provided l... Read More about Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies.

A multifunctional micropore-forming bioink with enhanced anti-bacterial and anti-inflammatory properties (2022)
Journal Article
Wang, M., Li, W., Luo, Z., Tang, G., Mu, X., Kuang, X., …Zhang, Y. S. (2022). A multifunctional micropore-forming bioink with enhanced anti-bacterial and anti-inflammatory properties. Biofabrication, 14(2), Article 024105. https://doi.org/10.1088/1758-5090/ac5936

Three-dimensional (3D) bioprinting has emerged as an enabling tool for various biomedical applications, such as tissue regeneration and tissue model engineering. To this end, the development of bioinks with multiple functions plays a crucial role in... Read More about A multifunctional micropore-forming bioink with enhanced anti-bacterial and anti-inflammatory properties.

Rational design of hydrogels for immunomodulation (2022)
Journal Article
Bu, W., Wu, Y., Ghaemmaghami, A. M., Sun, H., & Mata, A. (2022). Rational design of hydrogels for immunomodulation. Regenerative Biomaterials, 9, Article rbac009. https://doi.org/10.1093/rb/rbac009

The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development, repair and regeneration. Traditional immunomodulatory biologics exhibit limitations including degradation by enzymes, short half-li... Read More about Rational design of hydrogels for immunomodulation.

MicroRNA-511-3p Mediated Modulation of the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Controls LPS-Induced Inflammatory Responses in Human Monocyte Derived DCs (2022)
Journal Article
Awuah, D., Ruisinger, A., Alobaid, M., Mbadugha, C., & Ghaemmaghami, A. M. (2022). MicroRNA-511-3p Mediated Modulation of the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Controls LPS-Induced Inflammatory Responses in Human Monocyte Derived DCs. Immuno, 2(1), 104-117. https://doi.org/10.3390/immuno2010008

Abstract: The peroxisome proliferator-activated receptor gamma (PPAR) is a ligand-activated transcription factor expressed in dendritic cells (DCs), where it exerts anti-inflammatory responses against TLR4-induced inflammation. Recently, microRNA-511... Read More about MicroRNA-511-3p Mediated Modulation of the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Controls LPS-Induced Inflammatory Responses in Human Monocyte Derived DCs.