Skip to main content

Research Repository

Advanced Search

Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing

Latif, Arsalan; Fisher, Leanne E.; Dundas, Adam A.; Crucitti, Valentina Cuzzucoli; Imir, Zeynep; Lawler, Karen; Pappalard, Francesco; Muir, Benjamin W; Wildman, Ricky; Irvine, Derek J.; Alexander, Morgan R; Ghaemmaghami, Amir M.

Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing Thumbnail


Authors

Arsalan Latif

ADAM DUNDAS ADAM.DUNDAS1@NOTTINGHAM.AC.UK
Assistant Professor

Zeynep Imir

Karen Lawler

Francesco Pappalard

Benjamin W Muir

RICKY WILDMAN RICKY.WILDMAN@NOTTINGHAM.AC.UK
Professor of Multiphase Flow and Mechanics

DEREK IRVINE derek.irvine@nottingham.ac.uk
Professor of Materials Chemistry

Profile Image

MORGAN ALEXANDER MORGAN.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Biomedical Surfaces



Abstract

Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell type involved in the formation of granulation tissue, essential for effective wound healing. 315 different polymer surfaces are screened to identify candidates which actively drive fibroblasts toward either pro- or antiproliferative functional phenotypes. Fibroblast-instructive chemistries are identified, which are synthesized into surfactants to fabricate easy to administer microparticles for direct application to diabetic wounds. The pro-proliferative microfluidic derived particles are able to successfully promote neovascularization, granulation tissue formation, and wound closure after a single application to the wound bed. These active novel bio-instructive microparticles show great potential as a route to reducing the burden of chronic wounds.

Citation

Latif, A., Fisher, L. E., Dundas, A. A., Crucitti, V. C., Imir, Z., Lawler, K., …Ghaemmaghami, A. M. (2022). Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing. Advanced Materials, Article 2208364. https://doi.org/10.1002/adma.202208364

Journal Article Type Article
Acceptance Date Nov 20, 2022
Online Publication Date Nov 28, 2022
Publication Date Nov 28, 2022
Deposit Date Nov 30, 2022
Publicly Available Date Nov 30, 2022
Journal Advanced Materials
Print ISSN 0935-9648
Electronic ISSN 1521-4095
Publisher Wiley
Peer Reviewed Peer Reviewed
Article Number 2208364
DOI https://doi.org/10.1002/adma.202208364
Keywords Mechanical Engineering; Mechanics of Materials; General Materials Science
Public URL https://nottingham-repository.worktribe.com/output/14313877
Publisher URL https://onlinelibrary.wiley.com/doi/10.1002/adma.202208364

Files




You might also like



Downloadable Citations