Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing

Latif, Arsalan; Fisher, Leanne E.; Dundas, Adam A.; Crucitti, Valentina Cuzzucoli; Imir, Zeynep; Lawler, Karen; Pappalard, Francesco; Muir, Benjamin W; Wildman, Ricky; Irvine, Derek J.; Alexander, Morgan R; Ghaemmaghami, Amir M.

Abstract

Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell type involved in the formation of granulation tissue, essential for effective wound healing. 315 different polymer surfaces are screened to identify candidates which actively drive fibroblasts toward either pro- or antiproliferative functional phenotypes. Fibroblast-instructive chemistries are identified, which are synthesized into surfactants to fabricate easy to administer microparticles for direct application to diabetic wounds. The pro-proliferative microfluidic derived particles are able to successfully promote neovascularization, granulation tissue formation, and wound closure after a single application to the wound bed. These active novel bio-instructive microparticles show great potential as a route to reducing the burden of chronic wounds.

Citation

Latif, A., Fisher, L. E., Dundas, A. A., Crucitti, V. C., Imir, Z., Lawler, K., Pappalard, F., Muir, B. W., Wildman, R., Irvine, D. J., Alexander, M. R., & Ghaemmaghami, A. M. (2024). Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing. Advanced Materials, 36(43), Article 2208364. https://doi.org/10.1002/adma.202208364

• Journal Article Type: Article
• Acceptance Date: Nov 20, 2022
• Online Publication Date: Nov 28, 2022
• Publication Date: Oct 24, 2024
• Deposit Date: Nov 30, 2022
• Publicly Available Date: Nov 30, 2022
• Journal: Advanced Materials
• Print ISSN: 0935-9648
• Electronic ISSN: 1521-4095
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 36
• Issue: 43
• Article Number: 2208364
• DOI: https://doi.org/10.1002/adma.202208364
• Keywords: Mechanical Engineering; Mechanics of Materials; General Materials Science
• Public URL: https://nottingham-repository.worktribe.com/output/14313877
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202208364