Immune-instructive materials as new tools for immunotherapy

Fisher, Leanne E.; Kämmerling, Lisa; Alexander, Morgan R; Ghaemmaghami, Amir M

Abstract

Immune instructive materials, are materials with the ability to modulate or mimic the function of immune cells, provide exciting opportunities for developing new therapies in many areas including medical devices, chronic inflammation, cancer, and autoimmune diseases. In this review we highlight some of the latest research involving material-based strategies for modulating macrophage phenotype and dendritic cell function, as well as a brief description on biomaterial use in T cell and natural killer cell engineering. We highlight studies on material topography, size, shape and surface chemistry to reduce inflammation, along with scaffold and hydrogel delivery systems that are used for modulating DC phenotype and influencing T cell polarization. Artificial antigen presenting cells are also reviewed as a promising approach to cancer immunotherapy.

Citation

Fisher, L. E., Kämmerling, L., Alexander, M. R., & Ghaemmaghami, A. M. (2022). Immune-instructive materials as new tools for immunotherapy. Current Opinion in Biotechnology, 74, 194-203. https://doi.org/10.1016/j.copbio.2021.11.005

• Journal Article Type: Article
• Acceptance Date: Dec 24, 2021
• Online Publication Date: Dec 24, 2021
• Publication Date: 2022-04
• Deposit Date: Feb 17, 2022
• Publicly Available Date: Dec 25, 2022
• Journal: Current Opinion in Biotechnology
• Print ISSN: 0958-1669
• Electronic ISSN: 1879-0429
• Publisher: Elsevier BV
• Peer Reviewed: Peer Reviewed
• Volume: 74
• Pages: 194-203
• DOI: https://doi.org/10.1016/j.copbio.2021.11.005
• Keywords: Biomedical Engineering; Bioengineering; Biotechnology
• Public URL: https://nottingham-repository.worktribe.com/output/7171426
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0958166921002196?via%3Dihub