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All Outputs (23)

Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice (2023)
Journal Article

There is growing evidence that poor paternal diet at the time of conception increase the risk of offspring developing a range of non-communicable metabolic diseases, such as obesity, diabetes and cardiovascular disease, in adulthood. We hypothesise t... Read More about Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice.

Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development (2022)
Journal Article

As adults, our health can be influenced by a range of lifestyle and environmental factors, increasing the risk for developing a series of non-communicable diseases such as type 2 diabetes, heart disease and obesity. Over the past few decades, our und... Read More about Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development.

Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice (2022)
Journal Article

The underlying mechanisms driving paternally-programmed metabolic disease in offspring remain poorly defined. We fed male C57BL/6 mice either a control normal protein diet (NPD; 18% protein) or an isocaloric low protein diet (LPD; 9% protein) for a m... Read More about Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.

Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism (2021)
Journal Article

In this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’ phospholipid and triglyceride metab... Read More about Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism.

Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice (2020)
Journal Article

Introduction Paternal low-protein diet can alter sperm methylation status, fetal growth and program offspring ill-health, however its impact on the placenta remains poorly defined. Here we examine the influence paternal low-protein diet has on fetal... Read More about Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice.

The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring (2020)
Journal Article

Study question: Do the long-term health outcomes following IVF differ depending upon the duration of embryo culture before transfer? Summary answer: Using a mouse model, we demonstrate that in male but not female offspring, adverse cardiovascular... Read More about The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring.

Paternal diet impairs F1 and F2 offspring vascular function through sperm and seminal plasma specific mechanisms in mice (2019)
Journal Article

Although the impact of maternal diet on adult offspring health is well characterized, the role that a father's diet has on his offspring's health remains poorly defined. We establish the significance of a sup-optimal paternal low protein diet for off... Read More about Paternal diet impairs F1 and F2 offspring vascular function through sperm and seminal plasma specific mechanisms in mice.

Tissue Morphology and Gene Expression Characterisation of Transplantable Adenocarcinoma Bearing Mice Exposed to Fluorodeoxyglucose-Conjugated Magnetic Nanoparticles (2018)
Journal Article

Fluorodeoxyglucose-conjugated magnetic nanoparticles, designed to target cancer cells with high specificity when heated by an alternating magnetic field, could provide a low-cost, non-toxic treatment for cancer. However, it is essential that the in v... Read More about Tissue Morphology and Gene Expression Characterisation of Transplantable Adenocarcinoma Bearing Mice Exposed to Fluorodeoxyglucose-Conjugated Magnetic Nanoparticles.

Paternal low protein diet programs preimplantation embryo gene expression, fetal growth and skeletal development in mice (2017)
Journal Article

© 2017 Elsevier B.V. Defining the mechanisms underlying the programming of early life growth is fundamental for improving adult health and wellbeing. While the association between maternal diet, offspring growth and adult disease risk is well-establi... Read More about Paternal low protein diet programs preimplantation embryo gene expression, fetal growth and skeletal development in mice.

Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation (2016)
Journal Article

Cells and organisms respond to nutrient deprivation by decreasing global rates of transcription, translation and DNA replication. To what extent such changes can be reversed is largely unknown. We examined the effect of maternal dietary restriction o... Read More about Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation.