Samuel Furse
Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism
Furse, Samuel; Watkins, Adam; Hojat, Nima; Smith, James; Williams, Huw; Chiarugi, Davide; Koulman, Albert
Authors
ADAM WATKINS Adam.Watkins@nottingham.ac.uk
Associate Professor
Nima Hojat
James Smith
HUW WILLIAMS HUW.WILLIAMS@NOTTINGHAM.AC.UK
Senior Research Fellow
Davide Chiarugi
Albert Koulman
Abstract
In this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’ phospholipid and triglyceride metabolism in F1 and F2 generations is described. Detailed lipid profiles were acquired from F1 neonate (3 weeks), F1 adult (16 weeks) and F2 neonate offspring in serum, liver, brain, heart and abdominal adipose tissues by MS and NMR. Using a purpose-built computational tool for analysing both phospholipid and fat metabolism as a network, we characterised the number, type and abundance of lipid variables in and between tissues (Lipid Traffic Analysis), finding a variety of reprogrammings associated with paternal diet. These results are important because they describe the long-term metabolic result of dietary intake by fathers. This analytical approach is important because it offers unparalleled insight into possible mechanisms for alterations in lipid metabolism throughout organisms.
Citation
Furse, S., Watkins, A., Hojat, N., Smith, J., Williams, H., Chiarugi, D., & Koulman, A. (2021). Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism. Communications Biology, 4, Article 163. https://doi.org/10.1038/s42003-021-01686-1
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 8, 2021 |
Online Publication Date | Feb 5, 2021 |
Publication Date | Feb 5, 2021 |
Deposit Date | Jan 26, 2021 |
Publicly Available Date | Mar 28, 2024 |
Journal | Communications Biology |
Electronic ISSN | 2399-3642 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Article Number | 163 |
DOI | https://doi.org/10.1038/s42003-021-01686-1 |
Public URL | https://nottingham-repository.worktribe.com/output/5270137 |
Publisher URL | https://www.nature.com/articles/s42003-021-01686-1 |
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Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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