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Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism

Furse, Samuel; Watkins, Adam; Hojat, Nima; Smith, James; Williams, Huw; Chiarugi, Davide; Koulman, Albert

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Authors

Samuel Furse

Nima Hojat

James Smith

HUW WILLIAMS HUW.WILLIAMS@NOTTINGHAM.AC.UK
Senior Research Fellow

Davide Chiarugi

Albert Koulman



Abstract

In this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’ phospholipid and triglyceride metabolism in F1 and F2 generations is described. Detailed lipid profiles were acquired from F1 neonate (3 weeks), F1 adult (16 weeks) and F2 neonate offspring in serum, liver, brain, heart and abdominal adipose tissues by MS and NMR. Using a purpose-built computational tool for analysing both phospholipid and fat metabolism as a network, we characterised the number, type and abundance of lipid variables in and between tissues (Lipid Traffic Analysis), finding a variety of reprogrammings associated with paternal diet. These results are important because they describe the long-term metabolic result of dietary intake by fathers. This analytical approach is important because it offers unparalleled insight into possible mechanisms for alterations in lipid metabolism throughout organisms.

Citation

Furse, S., Watkins, A., Hojat, N., Smith, J., Williams, H., Chiarugi, D., & Koulman, A. (2021). Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism. Communications Biology, 4, Article 163. https://doi.org/10.1038/s42003-021-01686-1

Journal Article Type Article
Acceptance Date Jan 8, 2021
Online Publication Date Feb 5, 2021
Publication Date Feb 5, 2021
Deposit Date Jan 26, 2021
Publicly Available Date Mar 28, 2024
Journal Communications Biology
Electronic ISSN 2399-3642
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 4
Article Number 163
DOI https://doi.org/10.1038/s42003-021-01686-1
Public URL https://nottingham-repository.worktribe.com/output/5270137
Publisher URL https://www.nature.com/articles/s42003-021-01686-1

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