High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry

Hook, Andrew L.; Scurr, David J.; Anderson, Daniel G.; Langer, Robert; Williams, Paul; Davies, Martyn C.; Alexander, Morgan R.

Abstract

Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requirements of certain biological systems. A high throughput methodology has been developed to screen a library of polymers for thermo-responsiveness, which has resulted in the identification of novel switchable materials. To elucidate the mechanism by which the materials switch, time-of-flight secondary ion mass spectrometry has been employed to analyse the top 2 nm of the polymer samples at different temperatures. The surface enrichment of certain molecular fragments has been identified by time-of-flight secondary ion mass spectrometry analysis at different temperatures, suggesting an altered molecular conformation. In one example, a switch between an extended and collapsed conformation is inferred.

Citation

Hook, A. L., Scurr, D. J., Anderson, D. G., Langer, R., Williams, P., Davies, M. C., & Alexander, M. R. (2013). High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry. Surface and Interface Analysis, 45(1), https://doi.org/10.1002/sia.4910

• Journal Article Type: Article
• Publication Date: Jan 1, 2013
• Deposit Date: Nov 26, 2015
• Publicly Available Date: Nov 26, 2015
• Journal: Surface and Interface Analysis
• Print ISSN: 0142-2421
• Electronic ISSN: 1096-9918
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Issue: 1
• DOI: https://doi.org/10.1002/sia.4910
• Keywords: Thermo-Responsive, Stimuli, Switchable, ToF-SIMS, Water Contact Angle, Polymer Microarray
• Public URL: https://nottingham-repository.worktribe.com/output/1003014
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/sia.4910/abstract
• Additional Information: This is the peer reviewed version of the following article: Hook, A. L., Scurr, D. J., Anderson, D. G., Langer, R., Williams, P., Davies, M. and Alexander, M. (2013), High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry Surf. Interface Anal., 45: 181–184. doi:10.1002/sia.4910 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/sia.4910/abstract; This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.