@article { , title = {High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry}, abstract = {Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requirements of certain biological systems. A high throughput methodology has been developed to screen a library of polymers for thermo-responsiveness, which has resulted in the identification of novel switchable materials. To elucidate the mechanism by which the materials switch, time-of-flight secondary ion mass spectrometry has been employed to analyse the top 2 nm of the polymer samples at different temperatures. The surface enrichment of certain molecular fragments has been identified by time-of-flight secondary ion mass spectrometry analysis at different temperatures, suggesting an altered molecular conformation. In one example, a switch between an extended and collapsed conformation is inferred.}, doi = {10.1002/sia.4910}, eissn = {1096-9918}, issn = {0142-2421}, issue = {1}, journal = {Surface and Interface Analysis}, publicationstatus = {Published}, publisher = {Wiley}, url = {https://nottingham-repository.worktribe.com/output/1003014}, volume = {45}, keyword = {Thermo-Responsive, Stimuli, Switchable, ToF-SIMS, Water Contact Angle, Polymer Microarray}, year = {2013}, author = {Hook, Andrew L. and Scurr, David J. and Anderson, Daniel G. and Langer, Robert and Williams, Paul and Davies, Martyn C. and Alexander, Morgan R.} }