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Outputs (30)

The IUPHAR/BPS Guide to PHARMACOLOGY in 2024 (2023)
Journal Article
Harding, S. D., Armstrong, J. F., Faccenda, E., Southan, C., Alexander, S. H., Davenport, A. P., …Davies, J. A. (2024). The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Nucleic Acids Research, 52(D1), D1438-D1449. https://doi.org/10.1093/nar/gkad944

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated, online database that provides succinct overviews and key references for pharmacological targets and their recommended experimental l... Read More about The IUPHAR/BPS Guide to PHARMACOLOGY in 2024.

Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38 (2023)
Journal Article
Armstrong, J. F., Campo, B., Alexander, S. P., Arendse, L. B., Cheng, X., Davenport, A. P., …Davies, J. A. (2023). Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38. British Journal of Pharmacology, 180(15), 1899-1929. https://doi.org/10.1111/bph.16144

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approache... Read More about Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.

Development of a novel cell-based, In-Cell Western/ERK assay system for the high-throughput screening of agonists acting on the delta-opioid receptor (2022)
Journal Article
Asghar, J., Latif, L., Alexander, S. P. H., & Kendall, D. A. (2022). Development of a novel cell-based, In-Cell Western/ERK assay system for the high-throughput screening of agonists acting on the delta-opioid receptor. Frontiers in Pharmacology, 13, Article 933356. https://doi.org/10.3389/fphar.2022.933356

Background: Extracellular signal-regulated kinases (ERKs) are important signaling mediators in mammalian cells and, as a result, one of the major areas of research focus. The detection and quantification of ERK phosphorylation as an index of activati... Read More about Development of a novel cell-based, In-Cell Western/ERK assay system for the high-throughput screening of agonists acting on the delta-opioid receptor.

Environmental pharmacology—Dosing the environment: IUPHAR review 36 (2022)
Journal Article
Connolly, C. N., Alexander, S. P., Davies, J. A., & Spedding, M. (2022). Environmental pharmacology—Dosing the environment: IUPHAR review 36. British Journal of Pharmacology, 179(23), 5172-5179. https://doi.org/10.1111/bph.15933

Pesticide action is predominantly measured as a toxicological outcome, with pharmacological impact of sublethal doses on bystander species left largely undocumented. Likewise, chronic exposure, which often results in responses different from acute ad... Read More about Environmental pharmacology—Dosing the environment: IUPHAR review 36.

Planning experiments: Updated guidance on experimental design and analysis and their reporting III (2022)
Journal Article
Curtis, M. J., Alexander, S. P. H., Cirino, G., George, C. H., Kendall, D. A., Insel, P. A., …Ahluwalia, A. (2022). Planning experiments: Updated guidance on experimental design and analysis and their reporting III. British Journal of Pharmacology, 179(15), 3907-3913. https://doi.org/10.1111/bph.15868

Scientists who plan to publish in British Journal of Pharmacology (BJP) must read this article before undertaking a study. This editorial provides guidance for the design of experiments. We have published previously two guidance documents on experime... Read More about Planning experiments: Updated guidance on experimental design and analysis and their reporting III.

Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review (2022)
Journal Article
Papapetropoulos, A., Topouzis, S., Alexander, S. P. H., Cortese‐Krott, M., Kendall, D. A., Martemyanov, K. A., …Ferdinandy, P. (2022). Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review. British Journal of Pharmacology, https://doi.org/10.1111/bph.16337

In 2023, seventy novel drugs received market authorization for the first time in either Europe (by the EMA and the MHRA) or in the United States (by the FDA). Confirming a steady recent trend, more than half of these drugs target rare diseases or int... Read More about Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review.

Community guidelines for GPCR ligand bias: IUPHAR review 32 (2022)
Journal Article
Kolb, P., Kenakin, T., Alexander, S. P. H., Bermudez, M., Bohn, L. M., Breinholt, C. S., …Gloriam, D. E. (2022). Community guidelines for GPCR ligand bias: IUPHAR review 32. British Journal of Pharmacology, 179(14), 3651-3674. https://doi.org/10.1111/bph.15811

GPCRs modulate a plethora of physiological processes and mediate the effects of one-third of FDA-approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This ‘biased signalling’ paradigm requ... Read More about Community guidelines for GPCR ligand bias: IUPHAR review 32.

Neuromolecular Mechanisms of Cannabis Action (2020)
Book Chapter
Adel, Y., & Alexander, S. P. (2021). Neuromolecular Mechanisms of Cannabis Action. In Cannabinoids and Neuropsychiatric Disorders (15-28). Springer International Publishing. https://doi.org/10.1007/978-3-030-57369-0_2

Most of our current understanding of the neuromolecular mechanisms of Cannabis action focusses on two plant cannabinoids, THC and CBD. THC acts primarily through presynaptic CB cannabinoid receptors to regulate neurotransmitter release in the brain,... Read More about Neuromolecular Mechanisms of Cannabis Action.