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Planning experiments: Updated guidance on experimental design and analysis and their reporting III

Curtis, Michael J.; Alexander, Stephen P. H.; Cirino, Giuseppe; George, Christopher H.; Kendall, David A.; Insel, Paul A.; Izzo, Angelo A.; Ji, Yong; Panettieri, Reynold A.; Patel, Hemal H.; Sobey, Christopher G.; Stanford, S. Clare; Stanley, Phil; Stefanska, Barbara; Stephens, Gary J.; Teixeira, Mauro M.; Vergnolle, Nathalie; Ahluwalia, Amrita


Michael J. Curtis

Giuseppe Cirino

Christopher H. George

David A. Kendall

Paul A. Insel

Angelo A. Izzo

Yong Ji

Reynold A. Panettieri

Hemal H. Patel

Christopher G. Sobey

S. Clare Stanford

Phil Stanley

Barbara Stefanska

Gary J. Stephens

Mauro M. Teixeira

Nathalie Vergnolle

Amrita Ahluwalia


Scientists who plan to publish in British Journal of Pharmacology (BJP) must read this article before undertaking a study. This editorial provides guidance for the design of experiments. We have published previously two guidance documents on experimental design and analysis (Curtis et al., 2015; Curtis et al., 2018). This update clarifies and simplifies the requirements on design and analysis for BJP manuscripts. This editorial also details updated requirements following an audit and discussion on best practice by the BJP editorial board. Explanations for the requirements are provided in the previous articles. Here, we address new issues that have arisen in the course of handling manuscripts and emphasise three aspects of design that continue to present the greatest challenge to authors: randomisation, blinded analysis and balance of group sizes.

Journal Article Type Editorial
Acceptance Date Jun 7, 2022
Online Publication Date Jun 7, 2022
Publication Date 2022-08
Deposit Date Dec 3, 2022
Journal British Journal of Pharmacology
Print ISSN 0007-1188
Electronic ISSN 1476-5381
Publisher Wiley
Peer Reviewed Not Peer Reviewed
Volume 179
Issue 15
Pages 3907-3913
Keywords Pharmacology
Public URL
Publisher URL